Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems
Patent
·
OSTI ID:1805644
Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC52-07NA27344
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA); The United States of America, Represented by the Secretary of Agriculture (Washington, DC); University of Connecticut (Farmington, CT)
- Patent Number(s):
- 10,953,085
- Application Number:
- 15/590,918
- OSTI ID:
- 1805644
- Country of Publication:
- United States
- Language:
- English
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