Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Pinoresinol-lariciresinol reductase: Substrate versatility, enantiospecificity, and kinetic properties

Journal Article · · Chirality
DOI:https://doi.org/10.1002/chir.23218· OSTI ID:1801006
Not provided.
Research Organization:
Washington State Univ., Pullman, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
FG03-97ER20259
OSTI ID:
1801006
Journal Information:
Chirality, Journal Name: Chirality Journal Issue: 6 Vol. 32; ISSN 0899-0042
Publisher:
Wiley
Country of Publication:
United States
Language:
English

References (60)

Dirigent-mediated podophyllotoxin biosynthesis in Linum flavum and Podophyllum peltatum journal November 2000
Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia. journal December 1993
Dirigent phenoxy radical coupling advances and challenges journal August 2005
Eugenol specialty chemical production in transgenic poplar ( Populus tremula  ×  P. alba ) field trials journal March 2017
Crystal Structures of Pinoresinol-Lariciresinol and Phenylcoumaran Benzylic Ether Reductases and Their Relationship to Isoflavone Reductases journal September 2003
The Polyoxyphenols of Western red Cedar (Thuja Plicata Donn.): i. Isolation and Preliminary Characterization of Plicatic acid journal October 1959
Synthesis of biologically active tetrahydro-furofuranlignan-(syringin, pinoresinol)- mono- and bis-glucosides journal January 1991
Next Generation Sequencing in Predicting Gene Function in Podophyllotoxin Biosynthesis journal January 2013
Lignans and a stilbene from Festuca argentina journal January 1994
Justiciresinol, a New Furanoid Lignan from Justicia glauca journal November 1991
The constituents of Eucommia ulmoides Oliv. I. Isolation of (+)-medioresinol di-O-.BETA.-D-glucopyranoside. journal January 1983
Chavicol formation in sweet basil (Ocimum basilicum): cleavage of an esterified C9 hydroxyl group with NAD(P)H-dependent reduction journal January 2006
Flavonoid and other constituents of Bauhinia manca journal January 1988
Lignans from Nectandra turbacensis journal December 1986
Mechanisms of occupational asthma journal December 1999
Evolution of Plant Defense Mechanisms: RELATIONSHIPS OF PHENYLCOUMARAN BENZYLIC ETHER REDUCTASES TO PINORESINOL-LARICIRESINOL AND ISOFLAVONE REDUCTASES journal March 1999
Lignans of Horsfieldia iryaghedhi journal January 1982
Direct measurement of protein binding energetics by isothermal titration calorimetry journal September 2001
Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin journal June 2006
New lignans from the heartwood of cleistanthus collinus journal January 1981
Biosynthesis of antioxidant lignans in Sesamum indicum seeds journal February 1998
Novel benzylic ether reductions in lignan biogenesis in Forsythia intermedia journal June 1993
Phenolic constituents of phellodendron amurense bark journal December 1993
Stress responses in alfalfa (Medicago sativa L.) 11. Molecular cloning and expression of alfalfa isoflavone reductase, a key enzyme of isoflavonoid phytoalexin biosynthesis journal October 1991
A pinoresinol–lariciresinol reductase homologue from the creosote bush (Larrea tridentata) catalyzes the efficient in vitro conversion of p-coumaryl/coniferyl alcohol esters into the allylphenols chavicol/eugenol, but not the propenylphenols p-anol/isoeugenol journal September 2007
Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy journal March 2012
(+)-Pinoresinol/(+)-Lariciresinol Reductase from Forsythia intermedia : PROTEIN PURIFICATION, cDNA CLONING, HETEROLOGOUS EXPRESSION AND COMPARISON TO ISOFLAVONE REDUCTASE journal November 1996
Lignans from kernels of Virola michelii Heckel journal November 1995
Stereoselective Bimolecular Phenoxy Radical Coupling by an Auxiliary (Dirigent) Protein Without an Active Center journal January 1997
Characterization of the multiple catalytic activities of tartrate dehydrogenase journal February 1990
On the stereoselective synthesis of (+)-pinoresinol in Forsythia suspensa from its achiral precursor, coniferyl alcohol journal January 1992
Crystal Structures of Apo-form and Binary/Ternary Complexes of Podophyllum Secoisolariciresinol Dehydrogenase, an Enzyme Involved in Formation of Health-protecting and Plant Defense Lignans journal April 2005
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum journal January 2006
Camptothecin and Podophyllotoxin Derivatives: Inhibitors of Topoisomerase I and II ??? Mechanisms of Action, Pharmacokinetics and Toxicity Profile journal January 2006
Lignan biosynthesis in forsythia species journal January 1990
Chemical synthesis of the first lignans to be found in humans and animals journal January 1981
Assessment of a putative proton relay in Arabidopsis cinnamyl alcohol dehydrogenase catalysis journal January 2013
Lignans from Apollonias barbujana journal November 1995
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding journal May 1976
Enzymic Dehydrogenation of p-Coumaryl Alcohol I. Structure of Dimeric Compounds journal January 1975
Formation of lignans (-)-secoisolariciresinol and (-)-matairesinol with Forsythia intermedia cell-free extracts journal June 1991
Plant Anticancer Agents, XLII. Cytotoxic Constituents from Wikstroemia elliptica journal July 1986
Pinoresinol-Lariciresinol Reductases with Opposite Enantiospecificity Determine the Enantiomeric Composition of Lignans in the Different Organs of Linum usitatissimum L. journal May 2010
Induction of stress metabolite formation in suspension cultures of Vigna angularis journal January 1983
Secoisolariciresinol Dehydrogenase Purification, Cloning, and Functional Expression journal April 2001
Microbial oxidation of (+)-epimagnolin a by Aspergillus niger journal March 1994
Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis journal January 2004
Hinokinin biosynthesis in Linum corymbulosum Reichenb. journal September 2008
The Polyoxyphenols of Western red Cedar (Thuja Plicata Donn). ii. Degradation Studies on Plicatic Acid, a Possible Lignan acid journal December 1960
Phenolic Constituents of Selaginella doederleinii journal April 1994
Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester journal June 2006
Pinoresinol–lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum journal June 2005
Opposite Stereoselectivities of Dirigent Proteins in Arabidopsis and Schizandra Species journal August 2012
Molecular Cloning of Isoflavone Reductase from Pea (Pisum sativum L): Evidence for a 3R-Isoflavanone Intermediate in (+)-Pisatin Biosynthesis journal August 1994
Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis journal November 2019
Recombinant Pinoresinol-Lariciresinol Reductases from Western Red Cedar (Thuja plicata) Catalyze Opposite Enantiospecific Conversions journal January 1999
First highly stereoselective synthesis of (+)-dihydrosesamin, a trisubstituted tetrahydrofuran-type of lignan, by using highly erythro-selective aldol condensation journal January 2001
Lignan and neolignan glycosides from stems of Alangium premnifolium journal June 1997
Furanofuran lignan metabolism as a function of seed maturation in sesamum indicum: methylenedioxy bridge formation journal September 1998
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone journal September 2015

Similar Records

Recombinant pinoresinol/lariciresinol reductase, recombinant dirigent protein, and methods of use
Patent · Sun Dec 31 23:00:00 EST 2000 · OSTI ID:873645

Crystal structures of pinoresinol-lariciresinol,phenylcoumaranbenzylicether reductases and their relationship to isoflavone reductases
Journal Article · Tue Dec 31 23:00:00 EST 2002 · Journal of Biological Chemistry · OSTI ID:831728

Molecular basis and biological relevance of bacterial and plant pinoresinol/lariciresinol reductase specificities
Journal Article · Mon Jan 19 19:00:00 EST 2026 · Protein Science · OSTI ID:3015562