The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function

Jiang, Beichen; Adams, Zachary; Moonah, Shannon; Shi, Honglian; Maupin-Furlow, Julie; Moskovitz, Jackob

doi:10.3390/antiox9050452

Title: The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function

Journal Article · Sun May 24 00:00:00 EDT 2020 · Antioxidants

DOI:https://doi.org/10.3390/antiox9050452· OSTI ID:1800239

Jiang, Beichen ^[1];

^[2]; Moonah, Shannon ^[3]; Shi, Honglian ^[4];

^[5];

^[4]

Univ. of Kansas, Lawrence, KS (United States). Dept. of Pharmacology and Toxicology, School of Pharmacy
Univ. of Florida, Gainesville, FL (United States). Dept. of Microbiology and Cell Science, College of Agricultural and Life Sciences
Univ. of Virginia, Charlottesville, VA (United States). Division of Infectious Diseases
Univ. of Kansas, Lawrence, KS (United States). Dept. of Pharmacology and Toxicology, School of Pharmacy
Univ. of Florida, Gainesville, FL (United States). Dept. of Microbiology and Cell Science, College of Agricultural and Life Sciences

Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function. This modification is regulated by MetO reduction through the evolutionarily conserved methionine sulfoxide reductase (Msr) system. The Msr type A enzyme (MsrA) plays an important role as a cellular antioxidant and promotes cell survival. The ubiquitin- (Ub) like neddylation pathway, which is controlled by the c-Jun activation domain-binding protein-1 (Jab1), also affects cell survival. Jab1 negatively regulates expression of the cell cycle inhibitor cyclin-dependent kinase inhibitor 1B (P27) through binding and targeting P27 for ubiquitination and degradation. Here we report the finding that MsrA interacts with Jab1 and enhances Jab1's deneddylase activity (removal of Nedd8). In turn, an increase is observed in the level of deneddylated Cullin-1 (Cul-1, a component of E3 Ub ligase complexes). Furthermore, the action of MsrA increases the binding affinity of Jab1 to P27, while MsrA ablation causes a dramatic increase in P27 expression. Thus, an interaction between MsrA and Jab1 is proposed to have a positive effect on the function of Jab1 and to serve as a means to regulate cellular resistance to oxidative stress and to enhance cell survival.

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Research Organization:: Univ. of Florida, Gainesville, FL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division

Grant/Contract Number:: FG02-05ER15650

OSTI ID:: 1800239

Journal Information:: Antioxidants, Vol. 9, Issue 5; ISSN 2076-3921

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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ubiquitin
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Title: The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function

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