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Title: Design and Characterization of an Icosahedral Protein Cage Formed by a Double-Fusion Protein Containing Three Distinct Symmetry Elements

Journal Article · · ACS Synthetic Biology
 [1];  [1];  [2]; ORCiD logo [3]
  1. UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California 90095, United States; UCLA Department of Chemistry and Biochemistry, Los Angeles, California 90095, United States
  2. UCLA Department of Ecology and Evolutionary Biology, Los Angeles, California 90095, United States
  3. UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California 90095, United States; UCLA Department of Chemistry and Biochemistry, Los Angeles, California 90095, United States; UCLA Molecular Biology Institute, 611 Charles E Young Drive East, Los Angeles, California 90095, United States; California Nanosystems Institute, Los Angeles, California 90095, United States

Not provided.

Research Organization:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
FC02-02ER63421
OSTI ID:
1799609
Journal Information:
ACS Synthetic Biology, Vol. 9, Issue 3; ISSN 2161-5063
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (31)

The coming of age of de novo protein design journal September 2016
Nanohedra: Using symmetry to design self assembling protein cages, layers, crystals, and filaments journal February 2001
Design and Applications of Protein-Cage-Based Nanomaterials journal August 2016
High-symmetry protein assemblies: patterns and emerging applications journal April 2019
Structure of a 16-nm Cage Designed by Using Protein Oligomers journal May 2012
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy journal May 2012
Structure of a designed protein cage that self-assembles into a highly porous cube journal November 2014
Accurate design of co-assembling multi-component protein nanomaterials journal May 2014
Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression: Designed Protein Tetrahedron journal August 2015
Accurate design of megadalton-scale two-component icosahedral protein complexes journal July 2016
Evolution of a designed protein assembly encapsulating its own RNA genome journal December 2017
Rational Engineering of a Designed Protein Cage for siRNA Delivery journal July 2018
Multivalent Display of Antifreeze Proteins by Fusion to Self-Assembling Protein Cages Enhances Ice-Binding Activities journal November 2016
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system journal March 2018
A 3.8 Å resolution cryo-EM structure of a small protein bound to an imaging scaffold journal April 2019
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus journal March 2019
An ultra-stable gold-coordinated protein cage displaying reversible assembly journal May 2019
Geometric Principles for Designing Highly Symmetric Self-Assembling Protein Nanomaterials journal May 2017
Flexible, symmetry-directed approach to assembling protein cages journal July 2016
Self-Assembling Cages from Coiled-Coil Peptide Modules journal April 2013
Structure and Flexibility of Nanoscale Protein Cages Designed by Symmetric Self-Assembly journal May 2013
On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker journal August 2015
Designing and defining dynamic protein cage nanoassemblies in solution journal December 2016
Symmetry-Directed Self-Assembly of a Tetrahedral Protein Cage Mediated by de Novo-Designed Coiled Coils journal August 2017
Coiled-Coil-Mediated Assembly of an Icosahedral Protein Cage with Extremely High Thermal and Chemical Stability journal May 2019
Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium “Candidatus Nitrospira defluvii”: Identification of a catalytically important amino acid residue journal December 2010
A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology journal May 2012
Directed Evolution of a Protein Container journal February 2011
STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins journal July 2004
Principles for designing ordered protein assemblies journal December 2012
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017

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