Nanostructure-Initiator Mass Spectrometry Metabolite Analysis and Imaging

Greving, Matthew P.; Patti, Gary J.; Siuzdak, Gary

doi:10.1021/ac101565f

Nanostructure-Initiator Mass Spectrometry Metabolite Analysis and Imaging

Journal Article · Sat Jan 01 00:00:00 EST 2011 · Analytical Chemistry

DOI:https://doi.org/10.1021/ac101565f· OSTI ID:1788452

Greving, Matthew P. ^[1]; Patti, Gary J. ^[1]; Siuzdak, Gary ^[1]

The Scripps Research Inst., La Jolla, CA (United States). Scripps Center for Mass Spectrometry

Metabolites are downstream end products of gene and protein activity that closely correlate with the phenotype of a biological organism. Therefore, by observing specific metabolic changes, one can gain insight into perturbations underlying disease.(8) Consequently, increasing attention has been dedicated to analyzing metabolites using MS in the context of clinical diagnostics, understanding disease mechanisms, and identifying new therapeutic targets. The ability to analyze metabolites directly from biofluids and tissues continues to challenge current MS technology, largely because of the limits imposed by the complexity of these samples, which contain thousands to tens of thousands of metabolites. A new technology being developed to address this challenge is Nanostructure-Initiator MS (NIMS), a desorption/ionization approach that does not require the application of matrix and thereby facilitates small-molecule (i.e., metabolite) identification.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1788452

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 1 Vol. 83; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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