Transcriptional Regulation of Plant Biomass Degradation and Carbohydrate Utilization Genes in the Extreme Thermophile Caldicellulosiruptor bescii

Rodionov, Dmitry A.; Rodionova, Irina A.; Rodionov, Vladimir A.; Arzamasov, Aleksandr A.; Zhang, Ke; Rubinstein, Gabriel M.; Tanwee, Tania N. N.; Bing, Ryan G.; Crosby, James R.; Nookaew, Intawat; Basen, Mirko; Brown, Steven D.; Wilson, Charlotte M.; Klingeman, Dawn M.; Poole, II, Farris L.; Zhang, Ying; Kelly, Robert M.; Adams, Michael W. W.; Summers, ed., Zarath M.

doi:10.1128/mSystems.01345-20

Transcriptional Regulation of Plant Biomass Degradation and Carbohydrate Utilization Genes in the Extreme Thermophile Caldicellulosiruptor bescii

Journal Article · Tue Jun 29 00:00:00 EDT 2021 · mSystems

DOI:https://doi.org/10.1128/mSystems.01345-20· OSTI ID:1787883

^[1]; ^[2]; Rodionov, Vladimir A. ^[3]; Arzamasov, Aleksandr A. ^[1]; Zhang, Ke ^[4]; Rubinstein, Gabriel M. ^[5]; Tanwee, Tania N. N. ^[5]; Bing, Ryan G. ^[6]; Crosby, James R. ^[6]; Nookaew, Intawat ^[7]; ^[8]; Brown, Steven D. ^[9]; Wilson, Charlotte M. ^[10]; Klingeman, Dawn M. ^[9]; Poole, II, Farris L. ^[5]; ^[4]; Kelly, Robert M. ^[6]; ^[5]; Summers, ed., Zarath M.

Sanford-Burnhams-Prebys Medical Discovery Institute, La Jolla, California, USA, A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
Department of Bioengineering, University of California—San Diego, La Jolla, California, USA
A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
Department of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Mathematisch-Naturwissenschaftliche Fakultät, Institut für Biowissenschaften, Mikrobiologie, Universität Rostock, Rostock, Germany
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA, University of Otago, Dunedin, New Zealand

To develop functional metabolic engineering platforms for nonmodel microorganisms, a comprehensive understanding of the physiological and metabolic characteristics is critical. Caldicellulosiruptor bescii and other species in this genus have untapped potential for conversion of unpretreated plant biomass into industrial fuels and chemicals. The highly interactive and complex machinery used by C. bescii to acquire and process complex carbohydrates contained in lignocellulose was elucidated here to complement related efforts to develop a metabolic engineering platform with this bacterium.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: National Institutes of Health(NIH); USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725; SC0019391

OSTI ID:: 1787883

Alternate ID(s):: OSTI ID: 1819549

Journal Information:: mSystems, Journal Name: mSystems Journal Issue: 3 Vol. 6; ISSN 2379-5077

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

References (75)

Rex in Caldicellulosiruptor bescii : Novel regulon members and its effect on the production of ethanol and overflow metabolites Sander, Kyle; Chung, Daehwan; Hyatt, Doug MicrobiologyOpen, Vol. 8, Issue 2 https://doi.org/10.1002/mbo3.639	journal	April 2018
UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View Boutet, Emmanuel; Lieberherr, Damien; Tognolli, Michael Plant Bioinformatics https://doi.org/10.1007/978-1-4939-3167-5_2	book	January 2016
Software for analysis of bacterial genomes Mironov, A. A.; Vinokurova, N. P.; Gelfand, M. S. Molecular Biology, Vol. 34, Issue 2 https://doi.org/10.1007/BF02759643	journal	March 2000
Characterization of a recombinant cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus and its application in the production of mannose from glucose Park, Chang-Su; Kim, Jung-Eun; Choi, Jin-Geun Applied Microbiology and Biotechnology, Vol. 92, Issue 6 https://doi.org/10.1007/s00253-011-3403-3	journal	June 2011
The biology and biotechnology of the genus Caldicellulosiruptor: recent developments in ‘Caldi World’ Lee, Laura L.; Crosby, James R.; Rubinstein, Gabriel M. Extremophiles, Vol. 24, Issue 1 https://doi.org/10.1007/s00792-019-01116-5	journal	July 2019
Improved growth media and culture techniques for genetic analysis and assessment of biomass utilization by Caldicellulosiruptor bescii Farkas, Joel; Chung, Daehwan; Cha, Minseok Journal of Industrial Microbiology & Biotechnology, Vol. 40, Issue 1, p. 41-49 https://doi.org/10.1007/s10295-012-1202-1	journal	November 2012
Evaluation of the genus of Caldicellulosiruptor for production of 1,2-propanediol from methylpentoses Ingvadottir, Eva Maria; Scully, Sean Michael; Orlygsson, Johann Anaerobe, Vol. 47 https://doi.org/10.1016/j.anaerobe.2017.04.015	journal	October 2017
Pectin structure and biosynthesis Mohnen, D. Current Opinion in Plant Biology, Vol. 11, Issue 3 https://doi.org/10.1016/j.pbi.2008.03.006	journal	June 2008
Plant cell wall polymers as precursors for biofuels Pauly, Markus; Keegstra, Kenneth Current Opinion in Plant Biology, Vol. 13, Issue 3 https://doi.org/10.1016/j.pbi.2009.12.009	journal	June 2010
Evaluation and assessment of read-mapping by multiple next-generation sequencing aligners based on genome-wide characteristics Thankaswamy-Kosalai, Subazini; Sen, Partho; Nookaew, Intawat Genomics, Vol. 109, Issue 3-4 https://doi.org/10.1016/j.ygeno.2017.03.001	journal	July 2017
Comparative Genomic Reconstruction of Transcriptional Regulatory Networks in Bacteria Rodionov, Dmitry A. Chemical Reviews, Vol. 107, Issue 8 https://doi.org/10.1021/cr068309+	journal	July 2007
SignalP 4.0: discriminating signal peptides from transmembrane regions Petersen, Thomas Nordahl; Brunak, Søren; von Heijne, Gunnar Nature Methods, Vol. 8, Issue 10 https://doi.org/10.1038/nmeth.1701	journal	September 2011
Transcriptional control of central carbon metabolic flux in Bifidobacteria by two functionally similar, yet distinct LacI-type regulators Lanigan, Noreen; Kelly, Emer; Arzamasov, Aleksandr A. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-54229-4	journal	November 2019
Bacterial metal-sensing proteins exemplified by ArsR–SmtB family repressors Osman, Deenah; Cavet, Jennifer S. Natural Product Reports, Vol. 27, Issue 5 https://doi.org/10.1039/b906682a	journal	January 2010
Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization Pinchuk, Grigory E.; Rodionov, Dmitry A.; Yang, Chen Proceedings of the National Academy of Sciences, Vol. 106, Issue 8 https://doi.org/10.1073/pnas.0806798106	journal	February 2009
Control of Proteobacterial Central Carbon Metabolism by the HexR Transcriptional Regulator: A CASE STUDY IN Leyn, Semen A.; Li, Xiaoqing; Zheng, Qingxiang Journal of Biological Chemistry, Vol. 286, Issue 41 https://doi.org/10.1074/jbc.M111.267963	journal	August 2011
N -Acetylgalactosamine Utilization Pathway and Regulon in Proteobacteria: GENOMIC RECONSTRUCTION AND EXPERIMENTAL CHARACTERIZATION IN SHEWANELLA Leyn, Semen A.; Gao, Fang; Yang, Chen Journal of Biological Chemistry, Vol. 287, Issue 33 https://doi.org/10.1074/jbc.M112.382333	journal	June 2012
Comparative Genomics and Experimental Characterization of N -Acetylglucosamine Utilization Pathway of Shewanella oneidensis Yang, Chen; Rodionov, Dmitry A.; Li, Xiaoqing Journal of Biological Chemistry, Vol. 281, Issue 40 https://doi.org/10.1074/jbc.M605052200	journal	July 2006
The thermophilic biomass-degrading bacterium Caldicellulosiruptor bescii utilizes two enzymes to oxidize glyceraldehyde 3-phosphate during glycolysis Scott, Israel M.; Rubinstein, Gabriel M.; Poole, Farris L. Journal of Biological Chemistry, Vol. 294, Issue 25 https://doi.org/10.1074/jbc.RA118.007120	journal	May 2019
BEDTools: a flexible suite of utilities for comparing genomic features Quinlan, Aaron R.; Hall, Ira M. Bioinformatics, Vol. 26, Issue 6 https://doi.org/10.1093/bioinformatics/btq033	journal	January 2010
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes Yu, Nancy Y.; Wagner, James R.; Laird, Matthew R. Bioinformatics, Vol. 26, Issue 13 https://doi.org/10.1093/bioinformatics/btq249	journal	May 2010
Computer analysis of transcription regulatory patterns in completely sequenced bacterial genomes Mironov, A. Nucleic Acids Research, Vol. 27, Issue 14 https://doi.org/10.1093/nar/27.14.2981	journal	July 1999
The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes Overbeek, R. Nucleic Acids Research, Vol. 33, Issue 17 https://doi.org/10.1093/nar/gki866	journal	September 2005
Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex Chaix, D.; Ferguson, M. L.; Atmanene, C. Nucleic Acids Research, Vol. 38, Issue 17 https://doi.org/10.1093/nar/gkq334	journal	May 2010
Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum Kazanov, Marat D.; Li, Xiaoqing; Gelfand, Mikhail S. Nucleic Acids Research, Vol. 41, Issue 2 https://doi.org/10.1093/nar/gks1184	journal	December 2012
dbCAN: a web resource for automated carbohydrate-active enzyme annotation Yin, Yanbin; Mao, Xizeng; Yang, Jincai Nucleic Acids Research, Vol. 40, Issue W1 https://doi.org/10.1093/nar/gks479	journal	May 2012
A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae Nookaew, Intawat; Papini, Marta; Pornputtapong, Natapol Nucleic Acids Research, Vol. 40, Issue 20 https://doi.org/10.1093/nar/gks804	journal	September 2012
The Transporter Classification Database Saier, Milton H.; Reddy, Vamsee S.; Tamang, Dorjee G. Nucleic Acids Research, Vol. 42, Issue D1 https://doi.org/10.1093/nar/gkt1097	journal	November 2013
The carbohydrate-active enzymes database (CAZy) in 2013 Lombard, Vincent; Golaconda Ramulu, Hemalatha; Drula, Elodie Nucleic Acids Research, Vol. 42, Issue D1 https://doi.org/10.1093/nar/gkt1178	journal	November 2013
The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST) Overbeek, Ross; Olson, Robert; Pusch, Gordon D. Nucleic Acids Research, Vol. 42, Issue D1 https://doi.org/10.1093/nar/gkt1226	journal	November 2013
Computational analysis of bacterial RNA-Seq data McClure, Ryan; Balasubramanian, Divya; Sun, Yan Nucleic Acids Research, Vol. 41, Issue 14 https://doi.org/10.1093/nar/gkt444	journal	May 2013
KEGG as a reference resource for gene and protein annotation Kanehisa, Minoru; Sato, Yoko; Kawashima, Masayuki Nucleic Acids Research, Vol. 44, Issue D1 https://doi.org/10.1093/nar/gkv1070	journal	October 2015
The Pfam protein families database: towards a more sustainable future Finn, Robert D.; Coggill, Penelope; Eberhardt, Ruth Y. Nucleic Acids Research, Vol. 44, Issue D1 https://doi.org/10.1093/nar/gkv1344	journal	December 2015
Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses Liu, Ruijie; Holik, Aliaksei Z.; Su, Shian Nucleic Acids Research, Vol. 43, Issue 15 https://doi.org/10.1093/nar/gkv412	journal	April 2015
TransportDB 2.0: a database for exploring membrane transporters in sequenced genomes from all domains of life Elbourne, Liam D. H.; Tetu, Sasha G.; Hassan, Karl A. Nucleic Acids Research, Vol. 45, Issue D1 https://doi.org/10.1093/nar/gkw1068	journal	November 2016
Classification of 'Anaerocellum thermophilum' strain DSM 6725 as Caldicellulosiruptor bescii sp. nov. Yang, S. -J.; Kataeva, I.; Wiegel, J. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 60, Issue 9 https://doi.org/10.1099/ijs.0.017731-0	journal	October 2009
Stampy: A statistical algorithm for sensitive and fast mapping of Illumina sequence reads Lunter, G.; Goodson, M. Genome Research, Vol. 21, Issue 6 https://doi.org/10.1101/gr.111120.110	journal	October 2010
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Novel inositol catabolic pathway in Thermotoga maritima: Inositol catabolism in Thermotoga Rodionova, Irina A.; Leyn, Semen A.; Burkart, Michael D. Environmental Microbiology, Vol. 15, Issue 8 https://doi.org/10.1111/1462-2920.12096	journal	February 2013
C aldicellulosiruptor saccharolyticus transcriptomes reveal consequences of chemical pretreatment and genetic modification of lignocellulose Blumer‐Schuette, Sara E.; Zurawski, Jeffrey V.; Conway, Jonathan M. Microbial Biotechnology, Vol. 10, Issue 6 https://doi.org/10.1111/1751-7915.12494	journal	March 2017
Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima : Galacturonate catabolism Rodionova, Irina A.; Scott, David A.; Grishin, Nick V. Environmental Microbiology, Vol. 14, Issue 11 https://doi.org/10.1111/j.1462-2920.2012.02856.x	journal	August 2012
A Highly Thermostable Kanamycin Resistance Marker Expands the Tool Kit for Genetic Manipulation of Caldicellulosiruptor bescii Lipscomb, Gina L.; Conway, Jonathan M.; Blumer-Schuette, Sara E. Applied and Environmental Microbiology, Vol. 82, Issue 14 https://doi.org/10.1128/AEM.00570-16	journal	May 2016
A Novel Two-Component System, XygS/XygR, Positively Regulates Xyloglucan Degradation, Import, and Catabolism in Ruminiclostridium cellulolyticum Kampik, Clara; Denis, Yann; Pagès, Sandrine Applied and Environmental Microbiology, Vol. 86, Issue 20 https://doi.org/10.1128/AEM.01357-20	journal	October 2020
Comparative Analysis of Extremely Thermophilic Caldicellulosiruptor Species Reveals Common and Unique Cellular Strategies for Plant Biomass Utilization Zurawski, Jeffrey V.; Conway, Jonathan M.; Lee, Laura L. Applied and Environmental Microbiology, Vol. 81, Issue 20 https://doi.org/10.1128/AEM.01622-15	journal	August 2015
Functional Analysis of the Glucan Degradation Locus in Caldicellulosiruptor bescii Reveals Essential Roles of Component Glycoside Hydrolases in Plant Biomass Deconstruction Conway, Jonathan M.; McKinley, Bennett S.; Seals, Nathaniel L. Applied and Environmental Microbiology, Vol. 83, Issue 24 https://doi.org/10.1128/AEM.01828-17	journal	October 2017
Carbohydrate Utilization Patterns for the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus Reveal Broad Growth Substrate Preferences VanFossen, A. L.; Verhaart, M. R. A.; Kengen, S. M. W. Applied and Environmental Microbiology, Vol. 75, Issue 24 https://doi.org/10.1128/AEM.01959-09	journal	October 2009
Genus-Wide Assessment of Lignocellulose Utilization in the Extremely Thermophilic Genus Caldicellulosiruptor by Genomic, Pangenomic, and Metagenomic Analyses Lee, Laura L.; Blumer-Schuette, Sara E.; Izquierdo, Javier A. Applied and Environmental Microbiology, Vol. 84, Issue 9 https://doi.org/10.1128/AEM.02694-17	journal	February 2018
Identification of an ATPase, MsmK, Which Energizes Multiple Carbohydrate ABC Transporters in Streptococcus pneumoniae Marion, Carolyn; Aten, Andrew E.; Woodiga, Shireen A. Infection and Immunity, Vol. 79, Issue 10 https://doi.org/10.1128/IAI.05290-11	journal	October 2011
Genomic Reconstruction of the Transcriptional Regulatory Network in Bacillus subtilis Leyn, S. A.; Kazanov, M. D.; Sernova, N. V. Journal of Bacteriology, Vol. 195, Issue 11 https://doi.org/10.1128/JB.00140-13	journal	March 2013
Caldicellulosiruptor Core and Pangenomes Reveal Determinants for Noncellulosomal Thermophilic Deconstruction of Plant Biomass Blumer-Schuette, S. E.; Giannone, R. J.; Zurawski, J. V. Journal of Bacteriology, Vol. 194, Issue 15 https://doi.org/10.1128/JB.00266-12	journal	May 2012
Diversity and Versatility of the Thermotoga maritima Sugar Kinome Rodionova, I. A.; Yang, C.; Li, X. Journal of Bacteriology, Vol. 194, Issue 20 https://doi.org/10.1128/JB.01136-12	journal	August 2012
Ribulokinase and Transcriptional Regulation of Arabinose Metabolism in Clostridium acetobutylicum Zhang, L.; Leyn, S. A.; Gu, Y. Journal of Bacteriology, Vol. 194, Issue 5 https://doi.org/10.1128/JB.06241-11	journal	December 2011
Transcriptional Regulation of Central Carbon and Energy Metabolism in Bacteria by Redox-Responsive Repressor Rex Ravcheev, D. A.; Li, X.; Latif, H. Journal of Bacteriology, Vol. 194, Issue 5 https://doi.org/10.1128/JB.06412-11	journal	December 2011
Key Role for Sulfur in Peptide Metabolism and in Regulation of Three Hydrogenases in the Hyperthermophilic Archaeon Pyrococcus furiosus Adams, M. W. W.; Holden, J. F.; Menon, A. L. Journal of Bacteriology, Vol. 183, Issue 2 https://doi.org/10.1128/JB.183.2.716-724.2001	journal	January 2001
Transcriptional Regulation of Genes Encoding Arabinan-Degrading Enzymes in Bacillus subtilis Raposo, Maria Paiva; Inácio, José Manuel; Mota, Luís Jaime Journal of Bacteriology, Vol. 186, Issue 5 https://doi.org/10.1128/jb.186.5.1287-1296.2004	journal	March 2004
PaperBLAST: Text Mining Papers for Information about Homologs Price, Morgan N.; Arkin, Adam P. mSystems, Vol. 2, Issue 4 https://doi.org/10.1128/mSystems.00039-17	journal	August 2017
Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production Zhang, Ke; Zhao, Weishu; Rodionov, Dmitry A. mSystems https://doi.org/10.1128/mSystems.01351-20	journal	June 2021
Hemicelluloses Scheller, Henrik Vibe; Ulvskov, Peter Annual Review of Plant Biology, Vol. 61, Issue 1 https://doi.org/10.1146/annurev-arplant-042809-112315	journal	June 2010
SolexaQA: At-a-glance quality assessment of Illumina second-generation sequencing data Cox, Murray P.; Peterson, Daniel A.; Biggs, Patrick J. BMC Bioinformatics, Vol. 11, Issue 1 https://doi.org/10.1186/1471-2105-11-485	journal	September 2010
Genomic encyclopedia of sugar utilization pathways in the Shewanella genus Rodionov, Dmitry A.; Yang, Chen; Li, Xiaoqing BMC Genomics, Vol. 11, Issue 1 https://doi.org/10.1186/1471-2164-11-494	journal	January 2010
RegPrecise 3.0 – A resource for genome-scale exploration of transcriptional regulation in bacteria Novichkov, Pavel S.; Kazakov, Alexey E.; Ravcheev, Dmitry A. BMC Genomics, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2164-14-745	journal	January 2013
Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks Ravcheev, Dmitry A.; Godzik, Adam; Osterman, Andrei L. BMC Genomics, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2164-14-873	journal	January 2013
Genomic reconstruction of transcriptional regulatory networks in lactic acid bacteria Ravcheev, Dmitry A.; Best, Aaron A.; Sernova, Natalia V. BMC Genomics, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2164-14-94	journal	January 2013
voom: precision weights unlock linear model analysis tools for RNA-seq read counts Law, Charity W.; Chen, Yunshun; Shi, Wei Genome Biology, Vol. 15, Issue 2 https://doi.org/10.1186/gb-2014-15-2-r29	journal	January 2014
The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate Poudel, Suresh; Giannone, Richard J.; Basen, Mirko Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1076-1	journal	March 2018
Methylation by a Unique α-class N4-Cytosine Methyltransferase Is Required for DNA Transformation of Caldicellulosiruptor bescii DSM6725 Chung, Daehwan; Farkas, Joel; Huddleston, Jennifer R. PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0043844	journal	August 2012
The MsmX ATPase plays a crucial role in pectin mobilization by Bacillus subtilis Ferreira, Mário J.; Mendes, Aristides L.; de Sá-Nogueira, Isabel PLOS ONE, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pone.0189483	journal	December 2017
Transcriptional regulation of the carbohydrate utilization network in Thermotoga maritima Rodionov, Dmitry A.; Rodionova, Irina A.; Li, Xiaoqing Frontiers in Microbiology, Vol. 4 https://doi.org/10.3389/fmicb.2013.00244	journal	January 2013
Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria Rodionova, Irina A.; Li, Xiaoqing; Thiel, Vera Frontiers in Microbiology, Vol. 4 https://doi.org/10.3389/fmicb.2013.00407	journal	January 2013
Pan-genome analyses identify lineage- and niche-specific markers of evolution and adaptation in Epsilonproteobacteria Zhang, Ying; Sievert, Stefan M. Frontiers in Microbiology, Vol. 5 https://doi.org/10.3389/fmicb.2014.00110	journal	March 2014
Comparative genomics and evolution of regulons of the LacI-family transcription factors Ravcheev, Dmitry A.; Khoroshkin, Matvei S.; Laikova, Olga N. Frontiers in Microbiology, Vol. 5 https://doi.org/10.3389/fmicb.2014.00294	journal	June 2014
Transcriptional Regulation of Carbohydrate Utilization Pathways in the Bifidobacterium Genus Khoroshkin, Matvei S.; Leyn, Semen A.; Van Sinderen, Douwe Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.00120	journal	February 2016
Genomic Reconstruction of Carbohydrate Utilization Capacities in Microbial-Mat Derived Consortia Leyn, Semen A.; Maezato, Yukari; Romine, Margaret F. Frontiers in Microbiology, Vol. 8 https://doi.org/10.3389/fmicb.2017.01304	journal	July 2017
Comparative Genomics Reveals the Regulatory Complexity of Bifidobacterial Arabinose and Arabino-Oligosaccharide Utilization Arzamasov, Aleksandr A.; van Sinderen, Douwe; Rodionov, Dmitry A. Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.00776	journal	April 2018
Biohydrogen Production by the Thermophilic Bacterium Caldicellulosiruptor saccharolyticus: Current Status and Perspectives Bielen, Abraham; Verhaart, Marcel; van der Oost, John Life, Vol. 3, Issue 1 https://doi.org/10.3390/life3010052	journal	January 2013

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Transcriptional Regulation of Plant Biomass Degradation and Carbohydrate Utilization Genes in the Extreme Thermophile Caldicellulosiruptor bescii

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