Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production

Zhang, Ke; Zhao, Weishu; Rodionov, Dmitry A.; Rubinstein, Gabriel M.; Nguyen, Diep N.; Tanwee, Tania N. N.; Crosby, James; Bing, Ryan G.; Kelly, Robert M.; Adams, Michael W. W.; Zhang, Ying; Summers, ed., Zarath M.

doi:10.1128/mSystems.01351-20

Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production

Journal Article · Tue Jun 29 00:00:00 EDT 2021 · mSystems

DOI:https://doi.org/10.1128/mSystems.01351-20· OSTI ID:1787880

Zhang, Ke ^[1]; Zhao, Weishu ^[1]; Rodionov, Dmitry A. ^[2]; Rubinstein, Gabriel M. ^[3]; Nguyen, Diep N. ^[3]; Tanwee, Tania N. N. ^[3]; Crosby, James ^[4]; Bing, Ryan G. ^[4]; Kelly, Robert M. ^[4]; ^[3]; ^[1]; Summers, ed., Zarath M.

Department of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA
Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA, A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA

The extremely thermophilic cellulolytic bacterium, Caldicellulosiruptor bescii , degrades plant biomass at high temperatures without any pretreatments and can serve as a strategic platform for industrial applications. The metabolic engineering of C. bescii , however, faces potential bottlenecks in bio-based chemical productions.

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Research Organization:: University of Georgia, Athens, GA (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0019391

OSTI ID:: 1787880

Alternate ID(s):: OSTI ID: 1816925

Journal Information:: mSystems, Journal Name: mSystems Journal Issue: 3 Vol. 6; ISSN 2379-5077

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production

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