Electrostatic gating of ion transport in carbon nanotube porins: A modeling study

Yao, Yun-Chiao; Li, Zhongwu; Gillen, Alice J.; Yosinski, Shari; Reed, Mark A.; Noy, Aleksandr

doi:10.1063/5.0049550

Electrostatic gating of ion transport in carbon nanotube porins: A modeling study

Journal Article · Thu May 27 00:00:00 EDT 2021 · Journal of Chemical Physics

DOI:https://doi.org/10.1063/5.0049550· OSTI ID:1785438

Yao, Yun-Chiao ^[1]; ^[2]; ^[3]; Yosinski, Shari ^[4]; Reed, Mark A. ^[4]; ^[1]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Merced, CA (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Southeast Univ., Nanjing (China)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Yale Univ., New Haven, CT (United States)

Carbon nanotube porins (CNTPs) are biomimetic membrane channels that demonstrate excellent biocompatibility and unique water and ion transport properties. Gating transport in CNTPs with external voltage could increase control over ion flow and selectivity. Herein, we used continuum modeling to probe the parameters that enable and further affect CNTP gating efficiency, including the size and composition of the supporting lipid membrane, slip flow in the carbon nanotube, and the intrinsic electronic properties of the nanotube. Our results show that the optimal gated CNTP device consists of a semiconducting CNTP inserted into a small membrane patch containing an internally conductive layer. Moreover, we demonstrate that the ionic transport modulated by gate voltages is controlled by the charge distribution along the CNTP under the external gate electric potential. The theoretical understanding developed in this study offers valuable guidance for the design of gated CNTP devices for nanofluidic studies, novel biomimetic membranes, and cellular interfaces in the future.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC52-07NA27344; SC0019112

OSTI ID:: 1785438

Alternate ID(s):: OSTI ID: 1785026

Report Number(s):: LLNL-JRNL--820189; 1030488

Journal Information:: Journal of Chemical Physics, Journal Name: Journal of Chemical Physics Journal Issue: 20 Vol. 154; ISSN 0021-9606

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

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