Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids

Song, Yang; Wang, Mingming; Akkineni, Susrut; Yang, Wenchao; Hettige, Jeevapani J.; Jin, Haibao; Liao, Zhihao; Mu, Peng; Yan, Feng; Baer, Marcel; De Yoreo, James J.; Du, Dan; Lin, Yuehe; Chen, Chun-Long

doi:10.1021/acsmaterialslett.1c00110

Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids

Journal Article · Mon Mar 22 00:00:00 EDT 2021 · ACS Materials Letters

DOI:https://doi.org/10.1021/acsmaterialslett.1c00110· OSTI ID:1784559

^[1]; Wang, Mingming ^[2]; Akkineni, Susrut ^[2]; ^[2]; Hettige, Jeevapani J. ^[2]; ^[2]; Liao, Zhihao ^[2]; Mu, Peng ^[3]; Yan, Feng ^[4]; Baer, Marcel ^[2]; ^[2]; ^[5]; ^[5]; ^[6]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Washington State Univ., Pullman, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States); State Univ. of New York, Binghamton, NY (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Linyi Univ. Shandong (China)
Washington State Univ., Pullman, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)

Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited the high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. Furthermore, by programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

Grant/Contract Number:: AC05-76RL01830; AC02-05CH11231

OSTI ID:: 1784559

Report Number(s):: PNNL-SA--160450

Journal Information:: ACS Materials Letters, Journal Name: ACS Materials Letters Journal Issue: 4 Vol. 3; ISSN 2639-4979

Publisher:: ACS PublicationsCopyright Statement

Country of Publication:: United States

Language:: English

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