Peptoid-based membrane-mimetic two dimensional nanomaterials

Conference · Tue May 08 00:00:00 EDT 2018

DOI:https://doi.org/10.1117/12.2303685· OSTI ID:1481921

Chen, Chunlong ^[1]

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1. BATTELLE (PACIFIC NW LAB)

This paper presents a review of membrane-mimetic two dimensional (2D) nanomaterials assembled from sequence-defined, diblock-like peptoids through an evaporation-induced crystallization method. Similar to those associated with cell membranes, these peptoid-based nanomembranes exhibit thicknesses in the 3.5 - 5.6 nm range, spontaneous assembly at interfaces, thickness variations in response to changes in Na+ concentrations, and the ability to self-repair. Moreover, they are highly stable, free-standing, and atomically ordered. Both experimental and simulations studies showed that these nanomembranes were formed through an anisotropic formation process. We further demonstrated the incorporation and patterning of a broad range of functional groups within peptoid membranes through large side-chain diversity and/or co-crystallization approaches. By tuning the peptoid hydrophobic domains which determine the stability of nanomembranes, we demonstrated the assembly of single-walled crystalline nanotubes through folding peptoid-based 2D nanomaterials. Given peptoids are biocompatible and easy to synthesize, we anticipate this new class of peptoid-based 2D nanomaterials will provide a robust platform for development of biomimetic materials tailored to specific applications.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1481921
• Report Number(s): PNNL-SA-133246
• Resource Relation: Conference: Micro- and Nanotechnology Sensors, Systems, and Applications X, April 15-19, 2018,Orlando, Florida. Proceedings of the SPIE
• Country of Publication: United States
• Language: English