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Title: Mycobacterium tuberculosis Exploits a Heterohexameric Enoyl-CoA Hydratase Retro-Aldolase Complex for Cholesterol Catabolism

Journal Article · · Biochemistry
; ; ;

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783940
Report Number(s):
BNL-221471-2021-JACI
Journal Information:
Biochemistry, Vol. 58, Issue 41
Country of Publication:
United States
Language:
English

References (21)

Hit Generation in TB Drug Discovery: From Genome to Granuloma journal January 2018
Foamy macrophages and the progression of the human tuberculosis granuloma journal August 2009
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism journal July 2010
Mycobacterial persistence requires the utilization of host cholesterol journal March 2008
The Effect of Organic Acids on Mammalian Tubercle Bacilli journal October 1950
Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress journal January 2013
Identification of Mycobacterial Genes That Alter Growth and Pathology in Macrophages and in Mice journal September 2007
igr Genes and Mycobacterium tuberculosis Cholesterol Metabolism journal August 2009
A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol journal January 2010
Mycobacterium tuberculosis Utilizes a Unique Heterotetrameric Structure for Dehydrogenation of the Cholesterol Side Chain journal April 2013
A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis journal September 2014
Characterization of an Aldolase Involved in Cholesterol Side Chain Degradation in Mycobacterium tuberculosis journal January 2018
The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role journal March 2010
Gctf: Real-time CTF determination and correction journal January 2016
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling journal March 2000
Calculations and Publication-Quality Illustrations for Analytical Ultracentrifugation Data book January 2015
New developments in the ATSAS program package for small-angle scattering data analysis journal March 2012
Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy journal July 2016
The Catalytic Cycle of Biosynthetic Thiolase:  A Conformational Journey of an Acetyl Group through Four Binding Modes and Two Oxyanion Holes journal December 2002
Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site journal March 2018
FadA5 a Thiolase from Mycobacterium tuberculosis : A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis journal January 2015

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99 GENERAL AND MISCELLANEOUS