skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22-diene-24-oyl-CoA

Journal Article · · ACS Infectious Diseases
; ; ; ; ; ; ;

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1690152
Report Number(s):
BNL-220475-2020-JACI
Journal Information:
ACS Infectious Diseases, Vol. 6, Issue 8
Country of Publication:
United States
Language:
English

References (50)

Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress journal January 2013
Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates journal October 2010
A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol journal January 2010
Mycobacterial persistence requires the utilization of host cholesterol journal March 2008
Identification of Mycobacterial Genes That Alter Growth and Pathology in Macrophages and in Mice journal September 2007
Hit Generation in TB Drug Discovery: From Genome to Granuloma journal January 2018
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis: Transcriptional repressor controlling a large lipid metabolism regulon in mycobacteria journal July 2007
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages journal January 2007
A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis journal September 2014
Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis : ChsE4-ChsE5 α 2 β 2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA journal January 2015
Shrinking the FadE Proteome of Mycobacterium tuberculosis: Insights into Cholesterol Metabolism through Identification of an α 2 β 2 Heterotetrameric Acyl Coenzyme A Dehydrogenase Family journal October 2013
FadA5 a Thiolase from Mycobacterium tuberculosis : A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis journal January 2015
α-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters journal September 2015
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch journal August 2017
Characterization of Novel Acyl Coenzyme A Dehydrogenases Involved in Bacterial Steroid Degradation journal April 2015
Mycobacterium tuberculosis Exploits a Heterohexameric Enoyl-CoA Hydratase Retro-Aldolase Complex for Cholesterol Catabolism journal September 2019
Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase journal December 2015
Mechanisms and structures of crotonase superfamily enzymes – How nature controls enolate and oxyanion reactivity journal May 2008
Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket. journal October 1996
The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule 1 1Edited by D. Rees journal February 1998
Posttranslational regulation of microbial metabolism journal October 2015
Post-translational modifications as key regulators of bacterial metabolic fluxes journal April 2015
Lysine Succinylation and Lysine Malonylation in Histones journal March 2012
Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis journal January 2015
First Succinyl-Proteome Profiling of Extensively Drug-Resistant Mycobacterium tuberculosis Revealed Involvement of Succinylation in Cellular Physiology journal October 2014
Acetylome Analysis Reveals Diverse Functions of Lysine Acetylation in Mycobacterium tuberculosis journal September 2014
Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism journal April 2013
Reversible Acetylation and Inactivation of Mycobacterium tuberculosis Acetyl-CoA Synthetase Is Dependent on cAMP journal July 2011
Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis journal June 2013
Cyclic AMP-induced Conformational Changes in Mycobacterial Protein Acetyltransferases journal May 2012
Enoyl Coenzyme A Hydratase (Crotonase) journal August 1972
Substrate Stereochemistry of the Enoyl-CoA Hydratase Reaction journal May 1975
The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria. journal November 1975
Widespread and Enzyme-independent N ϵ -Acetylation and N ϵ -Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix journal August 2013
A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation journal April 2017
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis journal July 2008
Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases journal April 2014
Features and regulation of non-enzymatic post-translational modifications journal February 2018
Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling journal February 2017
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters journal September 2015
Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis journal March 2017
Rv0802c from Mycobacterium tuberculosis : the first structure of a succinyltransferase with the GNAT fold
  • Vetting, Matthew W.; Errey, James C.; Blanchard, John S.
  • Acta Crystallographica Section F Structural Biology and Crystallization Communications, Vol. 64, Issue 11 https://doi.org/10.1107/S1744309108031679
journal October 2008
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase journal November 2011
SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways journal June 2013
Cloning and characterization of NAD-dependent protein deacetylase (Rv1151c) from Mycobacterium tuberculosis journal July 2009
More than cholesterol catabolism: regulatory vulnerabilities in Mycobacterium tuberculosis journal June 2018
Data processing and analysis with the autoPROC toolbox journal March 2011
Phaser crystallographic software journal July 2007
Automated Structure Solution with the PHENIX Suite book January 2008
Coot model-building tools for molecular graphics journal November 2004

Similar Records

Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA
Journal Article · Sat Jan 01 00:00:00 EST 2022 · ACS Infectious Diseases · OSTI ID:1690152
+3 more
Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA
Journal Article · Wed Apr 07 00:00:00 EDT 2021 · ACS Infectious Diseases · OSTI ID:1690152
+3 more
Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis : ChsE4-ChsE5 α2β2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA
Journal Article · Thu Jan 08 00:00:00 EST 2015 · ACS Infectious Diseases · OSTI ID:1690152
+5 more

Related Subjects

99 GENERAL AND MISCELLANEOUS