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Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1

Journal Article · · ACS Chem. Biol.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NSF
OSTI ID:
1765181
Journal Information:
ACS Chem. Biol., Journal Name: ACS Chem. Biol. Journal Issue: (1) Vol. 16
Country of Publication:
United States
Language:
ENGLISH

References (28)

Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine 1 1 1Edited by R. Huber journal January 1999
Transient-State Kinetics of the Reaction of Aspartate Aminotransferase with Aspartate at Low pH Reveals Dual Routes in the Enzyme−Substrate Association Process journal November 1997
Features and development of Coot journal March 2010
Reaction specificity in pyridoxal phosphate enzymes journal January 2005
Design and Mechanism of ( S )-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction journal January 2018
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5′-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover journal September 2017
Data processing and analysis with the autoPROC toolbox journal March 2011
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition journal August 1997
Crystal structure of human recombinant ornithine aminotransferase journal March 1998
Design and Mechanism of Tetrahydrothiophene-Based γ-Aminobutyric Acid Aminotransferase Inactivators journal March 2015
Pyridoxal Phosphate Enzymes: Mechanistic, Structural, and Evolutionary Considerations journal June 2004
Mechanism of Inactivation of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid journal June 2019
Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs: ORNITHINE AMINOTRANSFERASE VS. GABA AMINOTRANSFERASE journal August 2014
Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways journal March 2017
Phaser crystallographic software journal July 2007
The reaction of ornithine aminotransferase with ornithine journal January 1982
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Stereochemistry of reaction paths at carbonyl centres journal January 1974
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid journal March 2020
Diazonamide toxins reveal an unexpected function for ornithine  -amino transferase in mitotic cell division journal February 2007
Application of the rule of shielding in the design of novel fluorinated structural motifs and peptidomimetics journal August 2013
Suicide enzyme inactivators journal September 1976
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Pyridoxal Enzymes: Mechanistic Diversity and Uniformity journal September 1995
Mechanistic Crystallography. Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1 R ,3 S ,4 S )-3-Amino-4-fluorocyclopentane-1-carboxylic Acid As Elucidated by Crystallography journal November 2004
Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase journal June 2015
Aminotransferases: demonstration of homology and division into evolutionary subgroups journal June 1993
Fluorine local environment: from screening to drug design journal August 2012

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