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Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane

Journal Article · · Biochem. J.
DOI:https://doi.org/10.1042/BCJ20210647· OSTI ID:1839711
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; OTHER
OSTI ID:
1839711
Journal Information:
Biochem. J., Vol. 478, Issue (23)
Country of Publication:
United States
Language:
ENGLISH

References (38)

Multiple DNA elements responsible for transcriptional regulation of the ornithine decarboxylase gene by protein kinase A. journal September 1992
Multisite Phosphorylation of Ornithine Decarboxylase in Transformed Macrophages Results in Increased Intracellular Enzyme Stability and Catalytic Efficiency journal October 1996
Mouse ornithine decarboxylase is phosphorylated by casein kinase-II at a predominant single location (serine 303) journal April 1991
Ornithine decarboxylase antizyme: a novel type of regulatory protein journal January 1996
Induction of a protein inhibitor to ornithine decarboxylase by the end products of its reaction. journal June 1976
Regulation of Ornithine Decarboxylase journal May 2006
Polyamine synthesis as a target of MYC oncogenes journal November 2018
The ornithine decarboxylase gene is a transcriptional target of c-Myc. journal August 1993
Polyamine metabolism and cancer: treatments, challenges and opportunities journal September 2018
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases journal May 2007
Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo journal October 2012
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial journal July 2009
A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma journal May 2015
Maintenance DFMO Increases Survival in High Risk Neuroblastoma journal September 2018
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial journal April 2008
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane journal June 2007
2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity journal April 1992
Altering the Reaction Specificity of Eukaryotic Ornithine Decarboxylase † , ‡ journal September 2000
Acidic Residues Important for Substrate Binding and Cofactor Reactivity in Eukaryotic Ornithine Decarboxylase Identified by Alanine Scanning Mutagenesis journal May 1995
1-Aminooxy-3-aminopropane reversibly prevents the proliferation of cultured baby hamster kidney cells by interfering with polyamine synthesis. journal August 1988
Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues journal January 1993
Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth11Abbreviations: AMA, S-(5′-deoxy-5′-adenosyl)-methylthioethyl-hydroxylamine; APA, 1-aminooxy-3-aminopropane; DFMO, alpha-difluoromethylornithine; DMEM, Dulbecco’s modified Eagle’s medium; DTT, dithiothreitol; EGF, epidermal growth factor; 5-FU, 5-fluorouracil; LDH, lactate dehydrogenase; MGBG, methyl-bisguanylhydrazone; SAM, S-adenosylmethionine; SAMDC, S-adenosylmethionine decarboxylase; and ODC, ornithine decarboxylase. journal January 2001
Crystal Structures and Solution Studies of Oxime Adducts of Mitochondrial Aspartate Aminotransferase journal March 1996
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif journal August 2010
The antizyme family: Polyamines and beyond journal October 2005
Prevention of Rapid Intracellular Degradation of ODC by a Carboxyl-Terminal Truncation journal March 1989
Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1 journal October 2015
Structural basis of antizyme-mediated regulation of polyamine homeostasis journal August 2015
Crystal structure of human ornithine decarboxylase at 2.1 å resolution: structural insights to antizyme binding journal January 2000
Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis journal December 2019
Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin journal January 2021
X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to d-Ornithine and to G418 journal June 2003
Structure of mammalian ornithine decarboxylase at 1.6 Å resolution: stereochemical implications of PLP-dependent amino acid decarboxylases journal May 1999
X-ray Structure of Ornithine Decarboxylase from Trypanosoma brucei :  The Native Structure and the Structure in Complex with α-Difluoromethylornithine † , ‡ journal November 1999
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal March 2011
Features and development of Coot journal March 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery journal October 2011

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