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Title: Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion

Journal Article · · Journal of the Mechanical Behavior of Biomedical Materials
 [1];  [2];  [1];  [1];  [1];  [3];  [3];  [3];  [1];  [1];  [1]
  1. Texas A & M Univ., College Station, TX (United States)
  2. Texas A & M Univ., College Station, TX (United States). Inst. for Preclinical Studies
  3. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
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Recently, predominantly closed-cell low density shape memory polymer (SMP) foam was reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Lastly, reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
Grant/Contract Number:
AC52-07NA27344; R01EB000462
OSTI ID:
1763946
Alternate ID(s):
OSTI ID: 1282115; OSTI ID: 1556639
Report Number(s):
LLNL-JRNL-651670; 772029
Journal Information:
Journal of the Mechanical Behavior of Biomedical Materials, Vol. 40, Issue na; ISSN 1751-6161
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 32 works
Citation information provided by
Web of Science

References (9)

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association journal March 2009
In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model
  • Rodriguez, Jennifer N.; Clubb, Fred J.; Wilson, Thomas S.
  • Journal of Biomedical Materials Research Part A, Vol. 102, Issue 5, p. 1231-1242 https://doi.org/10.1002/jbm.a.34782
journal May 2013
Treatment of type II endoleaks with a novel polyurethane thrombogenic foam: Induction of endoleak thrombosis and elimination of intra-aneurysmal pressure in the canine model journal August 2005
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms journal December 2010
Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water journal October 2012
Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms journal November 2011
Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams
  • Singhal, Pooja; Rodriguez, Jennifer N.; Small, Ward
  • Journal of Polymer Science Part B: Polymer Physics, Vol. 50, Issue 10, p. 724-737 https://doi.org/10.1002/polb.23056
journal March 2012
Estimating the Coefficient of Inertial Resistance in Fluid Flow Through Porous Media journal October 1974
Evaluation of a Novel Endoluminal Vascular Occlusion Device in a Porcine Model : Early and Late Follow-up journal August 2005

Cited By (4)

Advances in Biomaterials and Technologies for Vascular Embolization journal June 2019
Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials journal December 2017
Porous shape memory polymers: Design and applications journal January 2016
Shape-morphing composites with designed micro-architectures journal June 2016

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