Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

Muschenborn, Andrea D.; Ortega, Jason M.; Szafron, Jason M.; Szafron, David J.; Maitland, Duncan J.

doi:10.1186/1475-925x-12-103

Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

Journal Article · Sat Oct 12 00:00:00 EDT 2013 · Biomedical Engineering Online

DOI:https://doi.org/10.1186/1475-925x-12-103· OSTI ID:1626568

Muschenborn, Andrea D. ^[1]; Ortega, Jason M. ^[2]; Szafron, Jason M. ^[3]; Szafron, David J. ^[3]; Maitland, Duncan J. ^[3]

Texas A & M Univ., College Station, TX (United States); DOE/OSTI
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Texas A & M Univ., College Station, TX (United States)

Background: Shape memory polymer (SMP) foams are being investigated as an alternative aneurysm treatment method to embolic coils. The goal of both techniques is the reduction of blood flow into the aneurysm and the subsequent formation of a stable thrombus, which prevents future aneurysm rupture. The purpose of this study is to experimentally determine the parameters, permeability and form factor, which are related to the flow resistance imposed by both media when subjected to a pressure gradient. Methods: The porous media properties—permeability and form factor—of SMP foams and mock embolic coils (MECs) were measured with a pressure gradient method by means of an in vitro closed flow loop. We implemented the Forchheimer-Hazen-Dupuit-Darcy equation to calculate these properties. Mechanically-reticulated SMP foams were fabricated with average cell sizes of 0.7E-3 and 1.1E-3 m, while the MECs were arranged with volumetric packing densities of 11-28%. Results: The permeability of the SMP foams was an order of magnitude lower than that of the MECs. The form factor differed by up to two orders of magnitude and was higher for the SMP foams in all cases. The maximum flow rate of all samples tested was within the inertial laminar flow regime, with Reynolds numbers ranging between 1 and 35. Conclusions: The SMP foams impose a greater resistance to fluid flow compared to MECs, which is a result of increased viscous and inertial losses. These results suggest that aneurysms treated with SMP foam will have flow conditions more favorable for blood stasis than those treated with embolic coils having packing densities ≤ 28%.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1626568

Journal Information:: Biomedical Engineering Online, Journal Name: Biomedical Engineering Online Journal Issue: 1 Vol. 12; ISSN 1475-925X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Preparation and characterization of shape memory composite foams based on solid foaming method Yao, Y.; Zhou, T.; Xu, Y. Journal of Applied Polymer Science, Vol. 135, Issue 46 https://doi.org/10.1002/app.46767	journal	September 2018

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36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
42 ENGINEERING
Aneurysm treatment
Embolic coils
Engineering
FHDD
Forchheimer-Hazen-Dupuit-Darcy equation
Form factor
Permeability
SMP
Shape memory polymer foams

Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

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