Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

Muschenborn, Andrea D.; Ortega, Jason M.; Szafron, Jason M.; Szafron, David J.; Maitland, Duncan J.

doi:10.1186/1475-925x-12-103

Title: Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

Journal Article · Sat Oct 12 00:00:00 EDT 2013 · Biomedical Engineering Online

DOI:https://doi.org/10.1186/1475-925x-12-103· OSTI ID:1626568

Muschenborn, Andrea D. ^[1]; Ortega, Jason M. ^[2]; Szafron, Jason M. ^[1]; Szafron, David J. ^[1]; Maitland, Duncan J. ^[1]

Texas A & M Univ., College Station, TX (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Background: Shape memory polymer (SMP) foams are being investigated as an alternative aneurysm treatment method to embolic coils. The goal of both techniques is the reduction of blood flow into the aneurysm and the subsequent formation of a stable thrombus, which prevents future aneurysm rupture. The purpose of this study is to experimentally determine the parameters, permeability and form factor, which are related to the flow resistance imposed by both media when subjected to a pressure gradient. Methods: The porous media properties—permeability and form factor—of SMP foams and mock embolic coils (MECs) were measured with a pressure gradient method by means of an in vitro closed flow loop. We implemented the Forchheimer-Hazen-Dupuit-Darcy equation to calculate these properties. Mechanically-reticulated SMP foams were fabricated with average cell sizes of 0.7E-3 and 1.1E-3 m, while the MECs were arranged with volumetric packing densities of 11-28%. Results: The permeability of the SMP foams was an order of magnitude lower than that of the MECs. The form factor differed by up to two orders of magnitude and was higher for the SMP foams in all cases. The maximum flow rate of all samples tested was within the inertial laminar flow regime, with Reynolds numbers ranging between 1 and 35. Conclusions: The SMP foams impose a greater resistance to fluid flow compared to MECs, which is a result of increased viscous and inertial losses. These results suggest that aneurysms treated with SMP foam will have flow conditions more favorable for blood stasis than those treated with embolic coils having packing densities ≤ 28%.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Grant/Contract Number:: AC52-07NA27344; R01EB000462

OSTI ID:: 1626568

Journal Information:: Biomedical Engineering Online, Vol. 12, Issue 1; ISSN 1475-925X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

References (36)

Quality of Life after Stroke: The Importance of a Good Recovery Carod-Artal, Francisco Javier; Egido, José Antonio Cerebrovascular Diseases, Vol. 27, Issue 1 https://doi.org/10.1159/000200461	journal	January 2009
Cardiovascular Solid Mechanics Humphrey, Jay D. Springer New York https://doi.org/10.1007/978-0-387-21576-1	book	January 2002
Risk factors in intracranial saccular aneurysms Aspects on the formation and rupture of aneurysms, and development of cerebral vasospasm Østergaard, J. R. Acta Neurologica Scandinavica, Vol. 80, Issue 2 https://doi.org/10.1111/j.1600-0404.1989.tb03847.x	journal	August 1989
Permeability of open-cell foams under compressive strain Dawson, M. A.; Germaine, J. T.; Gibson, L. J. International Journal of Solids and Structures, Vol. 44, Issue 16 https://doi.org/10.1016/j.ijsolstr.2006.12.025	journal	August 2007
Biomedical applications of thermally activated shape memory polymers Small, IV, Ward; Singhal, Pooja; Wilson, Thomas S. Journal of Materials Chemistry, Vol. 20, Issue 17, p. 3356-3366 https://doi.org/10.1039/b923717h	journal	January 2010
Vascular Dynamics of a Shape Memory Polymer Foam Aneurysm Treatment Technique Ortega, Jason; Maitland, Duncan; Wilson, Tom Annals of Biomedical Engineering, Vol. 35, Issue 11 https://doi.org/10.1007/s10439-007-9358-y	journal	August 2007
Toward Real-Time Simulation of Blood-Coil Interaction during Aneurysm Embolization Wei, Yiyi; Cotin, Stéphane; Fang, Le Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009 https://doi.org/10.1007/978-3-642-04268-3_25	book	January 2009
Pressure Drops of Non-Newtonian Purely Viscous Fluid flow Through Synthetic Foams Sabiri, N. E.; Montillet, A.; Comiti, J. Chemical Engineering Communications, Vol. 156, Issue 1 https://doi.org/10.1080/00986449708936669	journal	February 1997
Post-polymerization crosslinked polyurethane shape memory polymers Hearon, Keith; Gall, Ken; Ware, Taylor Journal of Applied Polymer Science, Vol. 121, Issue 1, p. 144-153 https://doi.org/10.1002/app.33428	journal	February 2011
Healthy Lifestyle and the Risk of Stroke in Women Kurth, Tobias; Moore, Steven C.; Gaziano, J. Michael Archives of Internal Medicine, Vol. 166, Issue 13 https://doi.org/10.1001/archinte.166.13.1403	journal	July 2006
Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams Singhal, Pooja; Rodriguez, Jennifer N.; Small, Ward Journal of Polymer Science Part B: Polymer Physics, Vol. 50, Issue 10, p. 724-737 https://doi.org/10.1002/polb.23056	journal	March 2012
The Fundamental Theory of Flow Through Permeable Media from Darcy to Turbulence Lage, J. L. Transport Phenomena in Porous Media https://doi.org/10.1016/B978-008042843-7/50001-5	book	January 1998
Guglielmi detachable coil embolization of acute intracranial aneurysm: perioperative anatomical and clinical outcome in 403 patients Viñuela, Fernando; Duckwiler, Gary; Mawad, Michel Journal of Neurosurgery, Vol. 86, Issue 3 https://doi.org/10.3171/jns.1997.86.3.0475	journal	March 1997
Virtual Treatment of Basilar Aneurysms Using Shape Memory Polymer Foam Ortega, J. M.; Hartman, J.; Rodriguez, J. N. Annals of Biomedical Engineering, Vol. 41, Issue 4 https://doi.org/10.1007/s10439-012-0719-9	journal	January 2013
Permeability of open-pore microcellular materials Despois, J.; Mortensen, A. Acta Materialia, Vol. 53, Issue 5 https://doi.org/10.1016/j.actamat.2004.11.031	journal	March 2005
The effect of moisture absorption on the physical properties of polyurethane shape memory polymer foams Yu, Ya-Jen; Hearon, Keith; Wilson, Thomas S. Smart Materials and Structures, Vol. 20, Issue 8 https://doi.org/10.1088/0964-1726/20/8/085010	journal	July 2011
Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms Rodriguez, Jennifer N.; Yu, Ya-Jen; Miller, Matthew W. Annals of Biomedical Engineering, Vol. 40, Issue 4 https://doi.org/10.1007/s10439-011-0468-1	journal	November 2011
Non-Newtonian blood flow in human right coronary arteries: steady state simulations Johnston, Barbara M.; Johnston, Peter R.; Corney, Stuart Journal of Biomechanics, Vol. 37, Issue 5 https://doi.org/10.1016/j.jbiomech.2003.09.016	journal	May 2004
Shape memory polymers based on uniform aliphatic urethane networks Wilson, T. S.; Bearinger, J. P.; Herberg, J. L. Journal of Applied Polymer Science, Vol. 106, Issue 1, p. 540-551 https://doi.org/10.1002/app.26593	journal	January 2007
Estimation of aneurysm wall stresses created by treatment with a shape memory polymer foam device Hwang, Wonjun; Volk, Brent L.; Akberali, Farida Biomechanics and Modeling in Mechanobiology, Vol. 11, Issue 5, p. 715-729 https://doi.org/10.1007/s10237-011-0345-8	journal	September 2011
Hydraulic permeability of open-cell hydrophilic polyurethane foams Sefton, Michael V.; Lusher, Harris M. Journal of Applied Polymer Science, Vol. 25, Issue 10 https://doi.org/10.1002/app.1980.070251003	journal	October 1980
Relation between Aneurysm Volume, Packing, and Compaction in 145 Cerebral Aneurysms Treated with Coils Sluzewski, Menno; van Rooij, Willem Jan; Slob, Marian J. Radiology, Vol. 231, Issue 3 https://doi.org/10.1148/radiol.2313030460	journal	June 2004
An Introduction to Biomechanics Humphrey, Jay D.; Delange, Sherry L. Springer New York https://doi.org/10.1007/978-1-4899-0325-9	book	January 2004
Intracranial Aneurysm Enlargement on Serial Magnetic Resonance Angiography: Frequency and Risk Factors Burns, Joseph D.; Huston, John; Layton, Kennith F. Stroke, Vol. 40, Issue 2 https://doi.org/10.1161/STROKEAHA.108.519165	journal	February 2009
Dynamics of Blood Flow and Platelet Transport in Pathological Vessels Einav, Shmuel; Bluestein, Danny Annals of the New York Academy of Sciences, Vol. 1015, Issue 1 https://doi.org/10.1196/annals.1302.031	journal	May 2004
Haemodynamic simulation of aneurysm coiling in an anatomically accurate computational fluid dynamics model: technical note Mitsos, Aristotelis P.; Kakalis, Nikolaos M. P.; Ventikos, Yiannis P. Neuroradiology, Vol. 50, Issue 4 https://doi.org/10.1007/s00234-007-0334-x	journal	November 2007
Estimating the Coefficient of Inertial Resistance in Fluid Flow Through Porous Media Geertsma, J. Society of Petroleum Engineers Journal, Vol. 14, Issue 05 https://doi.org/10.2118/4706-PA	journal	October 1974
Non-Darcy Flow Through Fibrous Porous Media Beavers, G. S.; Sparrow, E. M. Journal of Applied Mechanics, Vol. 36, Issue 4 https://doi.org/10.1115/1.3564760	journal	December 1969
Introduction Humphrey, Jay D.; Delange, Sherry L. An Introduction to Biomechanics https://doi.org/10.1007/978-1-4899-0325-9_1	book	January 2004
About the use of fibrous materials in compact heat exchangers Tadrist, L.; Miscevic, M.; Rahli, O. Experimental Thermal and Fluid Science, Vol. 28, Issue 2-3 https://doi.org/10.1016/s0894-1777(03)00039-6	journal	January 2004
Intracranial Aneurysms Schievink, Wouter I. New England Journal of Medicine, Vol. 336, Issue 1 https://doi.org/10.1056/nejm199701023360106	journal	January 1997
Nonlinear Flow in Porous Media Ahmed, Nazeer; Sunada, Daniel K. Journal of the Hydraulics Division, Vol. 95, Issue 6 https://doi.org/10.1061/jyceaj.0002193	journal	November 1969
The Haemodynamics of Endovascular Aneurysm Treatment: A Computational Modelling Approach for Estimating the Influence of Multiple Coil Deployment Kakalis, N. M. P.; Mitsos, A. P.; Byrne, J. V. IEEE Transactions on Medical Imaging, Vol. 27, Issue 6 https://doi.org/10.1109/tmi.2008.915549	journal	June 2008
Using Porous Media Theory to Determine the Coil Volume Needed to Arrest Flow in Brain Aneurysms Knanafer, Khalil M.; Berguer, Ramon Porous Media https://doi.org/10.1201/9781420065428-10	book	August 2010
History of Endovascular Surgery: Personal Accounts of the Evolution Richling, Bernd Neurosurgery, Vol. 59, Issue suppl_5 https://doi.org/10.1227/01.neu.0000226224.79768.83	journal	November 2006
Historical Perspectives: The Microsurgical and Endovascular Treatment of Aneurysms Prestigiacomo, Charles J. Neurosurgery, Vol. 59, Issue suppl_5 https://doi.org/10.1227/01.neu.0000237438.35822.00	journal	November 2006

Cited By (2)

Preparation and characterization of shape memory composite foams based on solid foaming method Yao, Y.; Zhou, T.; Xu, Y. Journal of Applied Polymer Science, Vol. 135, Issue 46 https://doi.org/10.1002/app.46767	journal	September 2018
Numerical simulation of patient-specific endovascular stenting and coiling for intracranial aneurysm surgical planning Leng, Xiaochang; Wang, Yang; Xu, Jing Journal of Translational Medicine, Vol. 16, Issue 1 https://doi.org/10.1186/s12967-018-1573-9	journal	July 2018

Similar Records

Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion

Journal Article · Mon Dec 01 00:00:00 EST 2014 · Journal of the Mechanical Behavior of Biomedical Materials · OSTI ID:1626568

Rodriguez, Jennifer N.; Miller, Matthew W.; Boyle, Anthony; +8 more

Ultra Low Density Shape Memory Polymer Foams With Tunable Physicochemical Properties for Treatment of intracranial Aneurysms

Thesis/Dissertation · Sun Dec 01 00:00:00 EST 2013 · OSTI ID:1626568

Singhal, Pooja

A computational thrombus formation model: application to an idealized two-dimensional aneurysm treated with bare metal coils

Journal Article · Fri Aug 03 00:00:00 EDT 2018 · Biomechanics and Modeling in Mechanobiology · OSTI ID:1626568

Horn, John D.; Maitland, Duncan J.; Hartman, Jonathan; +1 more

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
42 ENGINEERING
36 MATERIALS SCIENCE
Engineering
Permeability
Form factor
SMP
Shape memory polymer foams
Embolic coils
FHDD
Forchheimer-Hazen-Dupuit-Darcy equation
Aneurysm treatment

Title: Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment

Citation Formats

References (36)

Cited By (2)

Similar Records

Related Subjects