Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion

Journal Article · · Journal of the Mechanical Behavior of Biomedical Materials
 [1];  [2];  [1];  [1];  [3];  [4];  [4];  [4];  [1];  [1];  [1]
  1. Texas A&M Univ., College Station, TX (United States). Dept. of Biomedical Engineering
  2. Texas A&M Univ., College Station, TX (United States). Texas Inst. for Preclinical Studies
  3. Texas A&M Univ., College Station, TX (United States). Dept. of Mechanical Engineering
  4. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
+ Show Author Affiliations

Recently, predominantly closed-cell low density shape memory polymer (SMP) foam was reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Lastly, reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
Grant/Contract Number:
AC52-07NA27344
OSTI ID:
1282115
Alternate ID(s):
OSTI ID: 1763946
OSTI ID: 1556639
Journal Information:
Journal of the Mechanical Behavior of Biomedical Materials, Journal Name: Journal of the Mechanical Behavior of Biomedical Materials Journal Issue: C Vol. 40; ISSN 1751-6161
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (9)

In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model
  • Rodriguez, Jennifer N.; Clubb, Fred J.; Wilson, Thomas S.
  • Journal of Biomedical Materials Research Part A, Vol. 102, Issue 5, p. 1231-1242 https://doi.org/10.1002/jbm.a.34782
journal May 2013
Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water journal October 2012
Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams
  • Singhal, Pooja; Rodriguez, Jennifer N.; Small, Ward
  • Journal of Polymer Science Part B: Polymer Physics, Vol. 50, Issue 10, p. 724-737 https://doi.org/10.1002/polb.23056
journal March 2012
Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms journal November 2011
Treatment of type II endoleaks with a novel polyurethane thrombogenic foam: Induction of endoleak thrombosis and elimination of intra-aneurysmal pressure in the canine model journal August 2005
Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association journal March 2009
Evaluation of a Novel Endoluminal Vascular Occlusion Device in a Porcine Model : Early and Late Follow-up journal August 2005
Estimating the Coefficient of Inertial Resistance in Fluid Flow Through Porous Media journal October 1974
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms journal December 2010

Cited By (4)

Shape-morphing composites with designed micro-architectures journal June 2016
Advances in Biomaterials and Technologies for Vascular Embolization journal June 2019
Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials journal December 2017
Porous shape memory polymers: Design and applications journal January 2016

Similar Records

Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment
Journal Article · Sat Oct 12 00:00:00 EDT 2013 · Biomedical Engineering Online · OSTI ID:1626568
Ultra Low Density Shape Memory Polymer Foams With Tunable Physicochemical Properties for Treatment of intracranial Aneurysms
Thesis/Dissertation · Sat Nov 30 23:00:00 EST 2013 · OSTI ID:1248313

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES