Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

Wu, Kun; Cleveland, Beth M.; Portman, Mark; Sealey, Wendy M.; Lei, Xin Gen

doi:10.3390/antiox10010016

Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

Journal Article · Sat Dec 26 23:00:00 EST 2020 · Antioxidants

DOI:https://doi.org/10.3390/antiox10010016· OSTI ID:1749956

Wu, Kun; ; Portman, Mark; Sealey, Wendy M.;

Microalgal docosahexaenoic acid (DHA) and astaxanthin (AST) may substitute for fish oil and synthetic AST in aquafeeds. This study explored the effects and mechanisms of those substitutions on AST metabolism and redox status of rainbow trout fed plant protein meal (PM)- or fishmeal (FM)-based diets. Two parallel experiments (PM vs. FM) were performed with 612 juvenile rainbow trout for 16 weeks as a 2 × 3 factorial arrangement of treatments with two AST sources (synthetic (SA) vs. microalgal (AA), at 80 mg/kg) and three levels (0, 50, and 100%) of fish oil substitutions with DHA-rich microalgae. The fish oil substitutions exhibit main effects (p < 0.05) and/or interactive effects (p < 0.05) with the source of AST on AST deposition, malondialdehyde and glutathione concentrations, and mRNA levels and activities of major redox enzymes (glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), and superoxide dismutase (SOD)) in the muscle and liver of trout fed both diet series. The AST source produced only differences in tissue AST deposition (p < 0.05) and number of metabolites. In conclusion, the substitutions of fish oil by the DHA-rich microalgae exerted more impacts than those of SA by AA on redox status and functional expression of antioxidant enzymes in the tissues of rainbow trout.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: EE0007091

OSTI ID:: 1749956

Alternate ID(s):: OSTI ID: 1848485

Journal Information:: Antioxidants, Journal Name: Antioxidants Journal Issue: 1 Vol. 10; ISSN 2076-3921; ISSN ANTIGE

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Switzerland

Language:: English

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Replacing fish oil and astaxanthin by microalgal sources produced different metabolic responses in juvenile rainbow trout fed 2 types of practical diets

Journal Article · Sun Dec 20 23:00:00 EST 2020 · Journal of Animal Science · OSTI ID:2287675

Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

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