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Title: Synthetic methylotrophy to liquid fuels and chemicals

Patent ·
OSTI ID:1735043
; ; ; ; ; ; ; ;

A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.

Research Organization:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Organization:
USDOE Advanced Research Projects Agency - Energy (ARPA-E)
DOE Contract Number:
AR0000432
Assignee:
University of Delaware (Newark, DE)
Patent Number(s):
10,717,964
Application Number:
16/042,257
OSTI ID:
1735043
Resource Relation:
Patent File Date: 07/23/2018
Country of Publication:
United States
Language:
English

References (20)

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Recombinant Cell and Method for Producing Isoprene patent-application November 2015
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Methods and Organisms for Utilizing Synthesis Gas or Other Gaseous Carbon Sources and Methanol patent-application March 2013
Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol patent April 2014
Synthetic methylotrophy to liquid fuels and chemicals patent August 2018
Microorganisms and Methods for Conversion of Syngas and Other Carbon Sources to Useful Products patent-application May 2014
Hyperphotosynthetic Organisms patent-application August 2009
Methylotrophic Bacterium for the Production of Recombinant Proteins and Other Proteins patent-application June 2003
Method for Producing Target Substance patent-application June 2003
Method for Producing Target Substance patent-application September 2004

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