Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Halloysite Clay Nanotubes as Carriers for Curcumin: Characterization and Application

Journal Article · · IEEE Transactions on Nanotechnology
 [1];  [2];  [2];  [3];  [3];  [2];  [4];  [2]
  1. Istituto di Nanotecnologia, Lecce (Italy); Louisiana State University
  2. Istituto di Nanotecnologia, Lecce (Italy)
  3. Univ. of Salento, Lecce (Italy)
  4. Louisiana Tech Univ., Ruston, LA (United States)
+ Show Author Affiliations
Halloysite is a nanostructured clay mineral with hollow tubular structure, which has recently found an important role as delivery system for drugs or other active molecules. One of these is curcumin, main constituent in the rhizome of the plant Curcuma Longa, with a series of useful pharmacological activities, hindered by its poor bioavalaibility and solubility in water. In this study, Halloysite clay nanotubes (HNTs) were characterized in terms of both structure and biocompatibility and they were used for curcumin delivery to cancer cells. The performed 3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay showed that HNTs have a high biocompatibility, also when coated with polymers, while curcumin is highly toxic for cancer cells. The release kinetics of curcumin from HNTs was investigated by the dialysis bag method, showing a slow and constant release of the drug, which can be further controlled by adding layers of polyelectrolytes to the external surface of the tubes. Successful polymer coating was followed by Zeta potential. The Trypan Blue assay showed a cytotoxic effect of loaded HNTs, proportional to the concentration of tubes and the incubation time. Successful HNTs uptake by breast cancer cells was demonstrated by Confocal Laser Scanning Microscopy images. All results indicate that HNTs are a promising carriers for polyphenol delivery and release.
Research Organization:
Louisiana State Univ., Baton Rouge, LA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
SC0012432
OSTI ID:
1673760
Journal Information:
IEEE Transactions on Nanotechnology, Journal Name: IEEE Transactions on Nanotechnology Journal Issue: 5 Vol. 15; ISSN 1536-125X
Publisher:
IEEECopyright Statement
Country of Publication:
United States
Language:
English

Cited By (3)

Silk fibroin/chitosan/halloysite composite medical dressing with antibacterial and rapid haemostatic properties journal November 2019
Thyme Oil Encapsulated in Halloysite Nanotubes for Antimicrobial Packaging System: Thyme oil encapsulated in nanoclay… journal March 2017
Clay-based drug-delivery systems: what does the future hold? journal July 2017

Figures / Tables (7)

Fig. 1(p. 1)figure Fig. 1
Table 1(p. 2)table Table 1
Fig. 2(p. 3)figure Fig. 2
Fig. 3(p. 4)figure Fig. 3
Fig. 4(p. 4)figure Fig. 4
Fig. 5(p. 4)figure Fig. 5
Fig. 6(p. 5)figure Fig. 6

Similar Records

The application of halloysite tubule nanoclay in drug delivery
Journal Article · Thu Apr 07 20:00:00 EDT 2016 · Expert Opinion on Drug Delivery · OSTI ID:1678714
Enzyme-activated intracellular drug delivery with tubule clay nanoformulation
Journal Article · Thu May 14 20:00:00 EDT 2015 · Scientific Reports · OSTI ID:1454260
Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway
Journal Article · Fri Aug 13 00:00:00 EDT 2010 · Biochemical and Biophysical Research Communications · OSTI ID:22202729

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
Biocompatibility
Curcumin
Cytotoxicity
Drug release
Drugs
Electron tubes
Halloysite nanotubes
Loading
Nanotubes
Phase locked loops
Scanning electron microscopy