Enzyme-activated intracellular drug delivery with tubule clay nanoformulation

Dzamukova, Maria R.; Naumenko, Ekaterina A.; Lvov, Yuri M.; Fakhrullin, Rawil F.

doi:10.1038/srep10560

Enzyme-activated intracellular drug delivery with tubule clay nanoformulation

Journal Article · Fri May 15 00:00:00 EDT 2015 · Scientific Reports

DOI:https://doi.org/10.1038/srep10560· OSTI ID:1454260

Dzamukova, Maria R. ^[1]; Naumenko, Ekaterina A. ^[2]; Lvov, Yuri M. ^[3]; Fakhrullin, Rawil F. ^[4]

Kazan Federal Univ., Kazan (Russian Federation). Bionanotechnology Lab.; None
Kazan Federal Univ., Kazan (Russian Federation). Bionanotechnology Lab.
Louisiana Tech Univ., Ruston, LA (United States). Inst. for Micromanufacturing
Kazan Federal Univ., Kazan (Russian Federation). Bionanotechnology Lab.; Louisiana Tech Univ., Ruston, LA (United States). Inst. for Micromanufacturing

Fabrication of stimuli-triggered drug delivery vehicle is is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (А549) as compared with hepatoma cells (Hep3b). In conclusion, the enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.

View Accepted Manuscript (DOE)

Research Organization:: Louisiana Tech Univ., Ruston, LA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0012432

OSTI ID:: 1454260

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 5; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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