Detection of metabolites of toxic alkylmethylphosphonates in biological samples. (Reannouncement with new availability information)
Technical Report
·
OSTI ID:166866
The major metabolites and breakdown products of some toxic organophosphonates are their respective alkylmethylphosphonic acids. These acids ionize at physiological pH and are not amenable to gas chromatographic analysis in their underivatized forms. Their detection in biological samples has been difficult because of their presence at only trace levels. Existing analytical methods were developed mainly for measuring these phosphonic acids in environmental samples and at higher concentrations. In this study, we devised a gas chromatographic/mass spectrometric method to provide confirmation and quantification of the organophosphonic acids of soman (GD), sarin (GB) and GF in blood and urine. This report describes the various derivatization conditions that we have studied and demonstrates the characteristic mass spectra by different ionization techniques. Detection methods, biological samples, urine, blood, gas chromatography/mass spectroscopy.
- Research Organization:
- Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 166866
- Report Number(s):
- AD-A--250687/1/XAB; USAMRICD-P--91-008
- Country of Publication:
- United States
- Language:
- English
Similar Records
Methodology and biological monitoring of exposure to chemical warfare agents
Metabolite pharmacokinetics of soman, sarin, and GF in rats and biological monitoring of exposure to toxic organophosphorus agents
Assay techniques for detection of exposure to sulfur mustard, cholinesterase inhibitors, sarin, soman, GF, and cyanide. Technical bulletin
Conference
·
Thu Jun 01 00:00:00 EDT 1995
·
OSTI ID:416159
Metabolite pharmacokinetics of soman, sarin, and GF in rats and biological monitoring of exposure to toxic organophosphorus agents
Technical Report
·
Thu May 13 00:00:00 EDT 1993
·
OSTI ID:7113592
Assay techniques for detection of exposure to sulfur mustard, cholinesterase inhibitors, sarin, soman, GF, and cyanide. Technical bulletin
Technical Report
·
Wed May 01 00:00:00 EDT 1996
·
OSTI ID:273712