Metabolite pharmacokinetics of soman, sarin, and GF in rats and biological monitoring of exposure to toxic organophosphorus agents

Technical Report · Thu May 13 04:00:00 EDT 1993

OSTI ID:7113592

Shih, M L; McMonagle, J D; Dolzine, T W; Gresham, V C

This study reports on the pharmacokinetics of the elimination of the metabolites of three toxic organophosphorus compounds (Soman, sarin, and GF). Urine, blood, and lung tissue were collected from rats dosed via subcutaneous route at 75 ug/Kg. Urinary excretion of the metabolite was the major elimination route for these three compounds. The major differences among them were primarily the extent and rate of excretion. The hydrolyzed form, alkylmethylphosphonic acid, was the single major metabolite formed and excreted in urine by a nonsaturable mechanism. Nearly total recoveries of the given doses for sarin and GF in metabolite form were obtained from the urine. The terminal elimination half-lives in urine were 6 and 15 hours for sarin and GF, respectively. Soman metabolite showed a biphasic elimination curve with terminal half-lives of 24 and 14 hours approximately. Soman was excreted at a slower rate with a recovery of only about 60%. Lung was the major organ of accumulation for soman. In blood the toxic agents were concentrated more in red blood cells than in plasma.

• Research Organization: Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
• OSTI ID: 7113592
• Report Number(s): AD-P-008827/8/XAB
• Country of Publication: United States
• Language: English

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