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Omics-Lethal Human Viruses, Ebola Experiment EH001

Dataset ·
 [1];  [2];  [3]
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
  3. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
+ Show Author Affiliations

The purpose of this experiment was to evaluate the human patient peripheral blood mononuclear cells (PBMC) response to Zaire Ebola Makona virus infection during the 2013-2016 epidemic in West Africa. Samples were obtained from whole blood collections from human patients in 2015 who were naturally infected with Ebola virus during the West African Ebola virus epidemic and healthy individuals (6 month collections) where resulting blood serum was processed for proteome, metabolome, and lipidome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Ebola virus infection.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Contributing Organization:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1661904
Report Number(s):
EH001; MassIVE: MSV000080129 (proteome, metabolome, lipidome)
Availability:
rc-support@pnnl.gov
Country of Publication:
United States
Language:
English

References (1)

Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis journal December 2017

Cited By (1)

PNNL DataHub Project Omics-LHV Profiling of Host Response to Ebola Infection Post-Processed Data Package DOIs dataset January 2021

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Data Download [schema:DataDownload]
Ebola virus [NCBITAXON:186536]
Human virus [NCIT:C14317]
Immune Response [GO:0006955]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Multi-omics [edam.topic:4021]
Omics [edam.topic:3391]
Time Sampled Measurement Datasets [IAO:0000584]
Virology [edam.topic:0781]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]