Wearable Sweat Band for Noninvasive Levodopa Monitoring

Tai, Li-Chia; Liaw, Tiffany S.; Lin, Yuanjing; Nyein, Hnin Y. Y.; Bariya, Mallika; Ji, Wenbo; Hettick, Mark; Zhao, Chunsong; Zhao, Jiangqi; Hou, Lei; Yuan, Zhen; Fan, Zhiyong; Javey, Ali

doi:10.1021/acs.nanolett.9b02478

Wearable Sweat Band for Noninvasive Levodopa Monitoring

Journal Article · Mon Aug 05 00:00:00 EDT 2019 · Nano Letters

DOI:https://doi.org/10.1021/acs.nanolett.9b02478· OSTI ID:1638994

^[1]; Liaw, Tiffany S. ^[1]; ^[2]; ^[1]; ^[1]; ^[1]; Hettick, Mark ^[1]; Zhao, Chunsong ^[1]; Zhao, Jiangqi ^[1]; Hou, Lei ^[1]; Yuan, Zhen ^[1]; ^[3]; ^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; Hong Kong Univ. of Science and Technology (China). Dept. of Electronic and Computer Engineering
Hong Kong Univ. of Science and Technology (China). Dept. of Electronic and Computer Engineering

Levodopa is the standard medication clinically prescribed to patients afflicted with Parkinson's disease. In particular, the monitoring and optimization of levodopa dosage are critical to mitigate the onset of undesired fluctuations in the patients' physical and emotional conditions such as speech function, motor behavior, and mood stability. The traditional approach to optimize levodopa dosage involves evaluating the subjects' motor function, which has many shortcomings due to its subjective and limited quantifiable nature. In this paper, we present a wearable sweat band on a nanodendritic platform that quantitatively monitors levodopa dynamics in the body. Both stationary iontophoretic induction and physical exercise are utilized as our methods of sweat extraction. The sweat band measures real-time pharmacokinetic profiles of levodopa to track the dynamic response of the drug metabolism. We demonstrated the sweat band's functionalities on multiple subjects with implications toward the systematic administering of levodopa and routine management of Parkinson's disease.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1638994

Journal Information:: Nano Letters, Journal Name: Nano Letters Journal Issue: 9 Vol. 19; ISSN 1530-6984

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Parkinson’s disease
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Wearable Sweat Band for Noninvasive Levodopa Monitoring

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