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Title: Methylxanthine Drug Monitoring with Wearable Sweat Sensors

Abstract

Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. In this paper, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.

Authors:
 [1]; ORCiD logo [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [1];  [1];  [1];  [1];  [2];  [1]
  1. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
  2. Sunchon National Univ., Suncheon (South Korea). Department of Printed Electronics Engineering
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF); Ministry of Food and Drug Safety in the Republic of Korea
OSTI Identifier:
1638977
Alternate Identifier(s):
OSTI ID: 1433448
Grant/Contract Number:  
AC02-05CH11231; 16163KKMFDS001
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Advanced Materials
Additional Journal Information:
Journal Volume: 30; Journal Issue: 23; Journal ID: ISSN 0935-9648
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION; drug monitoring; wearable biosensors; electrochemical sensors; flexible electronics

Citation Formats

Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, and Javey, Ali. Methylxanthine Drug Monitoring with Wearable Sweat Sensors. United States: N. p., 2018. Web. doi:10.1002/adma.201707442.
Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, & Javey, Ali. Methylxanthine Drug Monitoring with Wearable Sweat Sensors. United States. https://doi.org/10.1002/adma.201707442
Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, and Javey, Ali. Mon . "Methylxanthine Drug Monitoring with Wearable Sweat Sensors". United States. https://doi.org/10.1002/adma.201707442. https://www.osti.gov/servlets/purl/1638977.
@article{osti_1638977,
title = {Methylxanthine Drug Monitoring with Wearable Sweat Sensors},
author = {Tai, Li-Chia and Gao, Wei and Chao, Minghan and Bariya, Mallika and Ngo, Quynh P. and Shahpar, Ziba and Nyein, Hnin Y. Y. and Park, Hyejin and Sun, Junfeng and Jung, Younsu and Wu, Eric and Fahad, Hossain M. and Lien, Der-Hsien and Ota, Hiroki and Cho, Gyoujin and Javey, Ali},
abstractNote = {Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. In this paper, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.},
doi = {10.1002/adma.201707442},
url = {https://www.osti.gov/biblio/1638977}, journal = {Advanced Materials},
issn = {0935-9648},
number = 23,
volume = 30,
place = {United States},
year = {2018},
month = {4}
}

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Cited by: 11 works
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Works referenced in this record:

Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin
journal, April 2014


Screening for drugs of abuse in hair with ion spray LC–MS–MS
journal, October 2004


An ultra-lightweight design for imperceptible plastic electronics
journal, July 2013


Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
journal, January 2016


Urine Drug Testing of Chronic Pain Patients: Licit and Illicit Drug Patterns
journal, October 2008


Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers
journal, October 2002


Validation of the Direct Analysis in Real Time Source for Use in Forensic Drug Screening
journal, May 2009


Bio-sensing textile based patch with integrated optical detection system for sweat monitoring
journal, May 2009


Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance
journal, August 1998


Metabolic, catecholamine, and exercise performance responses to various doses of caffeine
journal, March 1995


Spheroid-based drug screen: considerations and practical approach
journal, February 2009


Caffeine and Performance
journal, June 1995


Human Saliva as a Diagnostic Specimen
journal, May 2001


A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring
journal, May 2016


Nanowire active-matrix circuitry for low-voltage macroscale artificial skin
journal, September 2010


The Erythromycin Breath Test For the Prediction of Drug Clearance
journal, January 2001


Drug Excretion in Human Eccrine Sweat
journal, March 1971


A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
journal, March 2016


Monitoring Opiate Use in Substance Abuse Treatment Patients With Sweat and Urine Drug Testing
journal, October 2000


Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials
journal, January 2005


User-interactive electronic skin for instantaneous pressure visualization
journal, July 2013


Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors
journal, April 2007


Sweat Testing in Opioid Users with a Sweat Patch
journal, October 1996


Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes
journal, October 2011


Ethnic Disparities in Unmet Need for Alcoholism, Drug Abuse, and Mental Health Care
journal, December 2001


Cardiovascular effects of caffeine in men and women
journal, April 2004


Caffeine Content of Specialty Coffees
journal, October 2003


Epidermal Electronics
journal, August 2011


A fully roll-to-roll gravure-printed carbon nanotube-based active matrix for multi-touch sensors
journal, December 2015


A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
journal, November 2016


Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System
journal, July 2016


Effects of moderate exercise on the pharmacokinetics of caffeine
journal, March 1991


Voltammetric sensor for caffeine based on a glassy carbon electrode modified with Nafion and graphene oxide
journal, June 2011


3D Printed “Earable” Smart Devices for Real-Time Detection of Core Body Temperature
journal, July 2017


Carbon nanotube coating improves neuronal recordings
journal, June 2008


Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
journal, April 2014


Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform
journal, April 2017


Interaction of the anticancer drug epirubicin with DNA
journal, June 2001


Hydrochromic conjugated polymers for human sweat pore mapping
journal, April 2014


Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
journal, May 2016


A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca 2+ and pH
journal, July 2016


Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
journal, July 2004


Highly deformable liquid-state heterojunction sensors
journal, September 2014


Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
journal, July 2013


    Works referencing / citing this record:

    Wearable flexible sweat sensors for healthcare monitoring: a review
    journal, October 2019


    Wearable biosensors for healthcare monitoring
    journal, February 2019


    Hydrogel Interferometry for Ultrasensitive and Highly Selective Chemical Detection
    journal, September 2018


    Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring
    journal, June 2019


    Rapid and sensitive detection of drugs of abuse in sweat by multiplexed capillary based immuno-biosensors
    journal, January 2020


    Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
    journal, August 2019


    Telecommunications and Data Processing in Flexible Electronic Systems
    journal, November 2019


    Nanomaterial‐Enabled Flexible and Stretchable Sensing Systems: Processing, Integration, and Applications
    journal, August 2019


    Recent advances of tissue-interfaced chemical biosensors
    journal, January 2020


    The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors
    journal, November 2019


    Weaving Sensing Fibers into Electrochemical Fabric for Real-Time Health Monitoring
    journal, September 2018


    Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad
    journal, July 2019


    Liquid‐State Optoelectronics Using Liquid Metal
    journal, January 2020


    Flexible Electrochemical Bioelectronics: The Rise of In Situ Bioanalysis
    journal, August 2019


    Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity
    journal, August 2019