Multivariate physiological recordings in an experimental hemorrhage model

Journal Article · Sun Apr 01 00:00:00 EDT 2018 · Data in Brief

DOI:https://doi.org/10.1016/j.dib.2018.01.053· OSTI ID:1630014

Yaghouby, Farid ^[1]; Daluwatte, Chathuri ^[2]; Marques, Nicole R. ^[3]; Khan, Muzna ^[3]; Salter, Michael ^[3]; Wolf, Jordan ^[3]; Nelson, Christina ^[3]; Salsbury, John ^[3]; Enkhbaatar, Perenlei ^[3]; Kinsky, Michael ^[3]; Strauss, David G. ^[4]; Kramer, George C. ^[3]; Scully, Christopher G. ^[2]

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1. US Food and Drug Administration, Silver Spring, MD (United States). Office of Science and Engineering Laboratories, Center for Devices and Radiological Health; DOE/OSTI
2. US Food and Drug Administration, Silver Spring, MD (United States). Office of Science and Engineering Laboratories, Center for Devices and Radiological Health
3. The University of Texas Medical Branch, Galveston, TX (United States). Department of Anesthesiology
4. US Food and Drug Administration, Silver Spring, MD (United States). Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research

In this paper we describe a data set of multivariate physiological measurements recorded from conscious sheep (N = 8; 37.4 ± 1.1 kg) during hemorrhage. Hemorrhage was experimentally induced in each animal by withdrawing blood from a femoral artery at two different rates (fast: 1.25 mL/kg/min; and slow: 0.25 mL/kg/min). Data, including physiological waveforms and continuous/intermittent measurements, were transformed to digital file formats (European Data Format [EDF] for waveforms and Comma-Separated Values [CSV] for continuous and intermittent measurements) as a comprehensive data set and stored and publicly shared here (Appendix A). The data set comprises experimental information (e.g., hemorrhage rate, animal weight, event times), physiological waveforms (arterial and central venous blood pressure, electrocardiogram), time-series records of non-invasive physiological measurements (SpO₂, tissue oximetry), intermittent arterial and venous blood gas analyses (e.g., hemoglobin, lactate, SaO₂, SvO₂) and intermittent thermodilution cardiac output measurements. A detailed explanation of the hemodynamic and pulmonary changes during hemorrhage is available in a previous publication (Scully et al., 2016)

• Research Organization: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
• Sponsoring Organization: Shriners Hospital for Children; U.S. Food and Drug Administration Medical Countermeasures Initiative; USDOE/Office of Science (SC); University of Texas Medical Branch Translational Intensive Care Unit; and an appointment to the Research Participation Program at the Center for Devices and Radiological Health
• Grant/Contract Number: SC0014664
• OSTI ID: 1630014
• Journal Information: Data in Brief, Journal Name: Data in Brief Journal Issue: C Vol. 17; ISSN 2352-3409
• Publisher: Elsevier
• Country of Publication: United States
• Language: English