GDP-L-fucose transport in plants: The missing piece
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint BioEnergy Institute and Environmental Genomics and Systems Biology Division; Univ. of Melbourne (Australia). School of BioSciences
The monosaccharide fucose is an important deoxyhexose occurring in plants, fungi and animals. Fucose is mainly found as a component of glycan structures such as N- and O-linked glycans, glycolipids and in cell wall polysaccharides such as fucoidan, xyloglucan, rhamnogalacturonan II. The biosynthesis of these glycan structures is mediated by glycosyltransferases and typically occurs within the endomembrane system. Fucosylation reactions require an activated sugar in the form of GDP-L-fucose (GDP-Fuc) which is either biosynthesized de novo or can also be salvaged from fucose in the cytosol. This partitioning necessitates active GDP-Fuc transport into the endomembrane system for glycosylation reactions. To date, GDP-Fuc transporters have been characterized in mammals (Homo sapiens), insects (Drosophila melanogaster) and nematodes (Caenorhabditis elegans), reviewed in. However, given the importance of fucose containing structures in plants, the absence of a characterized GDP-Fuc transporter has, until recently, been a dilemma. Thus, the recent identification of a GDP-Fuc transporter (GFT1) in the reference plant Arabidopsis thaliana represents the final missing piece of GDP-Fuc metabolism in plants.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- Grant/Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1629584
- Journal Information:
- Channels (Austin, Tex.), Vol. 11, Issue 1; ISSN 1933-6950
- Publisher:
- Taylor & FrancisCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum
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journal | May 2019 |
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