Quantile-dependent expressivity of postprandial lipemia

Williams, Paul T.

doi:10.1371/journal.pone.0229495

Quantile-dependent expressivity of postprandial lipemia

Journal Article · Wed Feb 26 00:00:00 EST 2020 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0229495· OSTI ID:1629514

^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DOE/OSTI

“Quantile-dependent expressivity” describes an effect of the genotype that depends upon the level of the phenotype (e.g., whether a subject’s triglycerides are high or low relative to its population distribution). Prior analyses suggest that the effect of a genetic risk score (GRS) on fasting plasma triglyceride levels increases with the percentile of the triglyceride distribution. Postprandial lipemia is well suited for testing quantile-dependent expressivity because it exposes each individual’s genotype to substantial increases in their plasma triglyceride concentrations. Ninety-seven published papers were identified that plotted mean triglyceride response vs. time and genotype, which were converted into quantitative data. Separately, for each published graph, standard least-squares regression analysis was used to compare the genotype differences at time t (dependent variable) to average triglyceride concentrations at time t (independent variable) to assess whether the genetic effect size increased in association with higher triglyceride concentrations and whether the phenomenon could explain purported genetic interactions with sex, diet, disease, BMI, and drugs.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1629514

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 2 Vol. 15; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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Genetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy Subjects Matikainen, Niina; Burza, Maria Antonella; Romeo, Stefano PLoS ONE, Vol. 8, Issue 11 https://doi.org/10.1371/journal.pone.0079473	journal	November 2013
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Pro12Ala Sequence Variant of the PPARG Gene Is Associated with Postprandial Hypertriglyceridemia in Non-E3/E3 Patients with the Metabolic Syndrome Cardona, Fernando; Morcillo, Sonsoles; Gonzalo-Marín, Montserrat Clinical Chemistry, Vol. 52, Issue 10 https://doi.org/10.1373/clinchem.2006.069690	journal	October 2006
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Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity Saleheen, D.; Natarajan, P.; Armean, Im Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.15568	text	January 2017
Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion Shatwan, Israa; Minihane, Anne-Marie; Williams, Christine International Journal of Molecular Sciences, Vol. 17, Issue 3 https://doi.org/10.3390/ijms17030397	journal	March 2016

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