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Imaging biomarkers in neurodegeneration: current and future practices

Journal Article · · Alzheimer's Research & Therapy
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [9];  [10];  [11];  [12];  [13];  [13];  [14];  [15];  [16];  [13];  [17]
  1. Univ. of Gothenburg (Sweden). Shalgrenska Univ. Hospital. Wallenberg Centre for Molecular and Translational Medicine. Dept. of Psychiatry and Neurochemistry; DOE/OSTI
  2. Univ. College London (United Kingdom). Centre for Medical image Computing (CMIC). Dept. of Computer Science. Dept. of Medical Physics and Biomedical Engineering
  3. Vrije Univ., Amsterdam (Netherlands). Amsterdam Neuroscience. Dept. of Radiology and Nuclear Medicine
  4. Univ. of Gothenburg (Sweden). Shalgrenska Univ. Hospital. Wallenberg Centre for Molecular and Translational Medicine. Dept. of Psychiatry and Neurochemistry
  5. Univ. of Manchester (United Kingdom). Division of Neuroscience and Experimental Psychology. Neuroscience and Aphasia Research Unit
  6. German Center for Neurodegenerative Diseases (DZNE), Magdeburg (Germany)
  7. Imperial College, London (United Kingdom). Division of Brain Sciences; Imperial College, London (United Kingdom). United Kingdom Dementia Research Inst.
  8. Cardiff Univ. (United Kingdom). Brain Research Imaging Centre (CUBRIC). School of Psychology
  9. Univ. College London (United Kingdom). UCL Inst. of Neurology. Dementia Research Centre; Univ. of Chile, Santiago (Chile). Faculty of Medicine. Dept. of Neurological Sciences
  10. German Center for Neurodegenerative Diseases (DZNE), Magdeburg (Germany); Otto-van Guericke Univ., Magdeburg (Germany). Inst. of Cognitive Neurology and Dementia Research
  11. Univ. of Dublin (Ireland). Trinity College
  12. Lund Univ. (Sweden). Dept. of Clinical Sciences Malmo. Clinical Memory Research Unit
  13. Univ. College London (United Kingdom). UCL Inst. of Neurology. Dementia Research Centre
  14. Lund Univ. (Sweden). Dept. of Clinical Sciences Malmo. Clinical Memory Research Unit; Karolinska Inst., Stockholm (Sweden). Dept. of Neurobiology, Care sciences and Society. Division of Clinical Geriatrics
  15. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Inst.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging
  16. Univ. of Cambridge (United Kingdom). School of Clinical Medicine. Dept. of Psychiatry; Univ. of Manchester (United Kingdom). MAHSC. Division of Neuroscience and Experimental Psychology. Wolfson Molecular Imaging Centre
  17. Univ. of Gothenburg (Sweden). Shalgrenska Univ. Hospital. Wallenberg Centre for Molecular and Translational Medicine. Dept. of Psychiatry and Neurochemistry; Univ. College London (United Kingdom). UCL Inst. of Neurology. Dementia Research Centre; Sahlgrenska Univ. Hospital, Gothenburg (Sweden). Dept. of Clinical Physiology
+ Show Author Affiliations
There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits both to the diagnosis and understanding of these diseases. This review forms part of a series of articles which stem from the University College London/University of Gothenburg course “Biomarkers in neurodegenerative diseases”. In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in research as well as new techniques being developed. We will also discuss the use of machine learning (ML) techniques within these fields to provide additional insights to early diagnosis and multimodal analysis.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1629510
Journal Information:
Alzheimer's Research & Therapy, Journal Name: Alzheimer's Research & Therapy Journal Issue: 1 Vol. 12; ISSN 1758-9193
Publisher:
BioMed CentralCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
Alzheimer’s disease
MRI
Machine learning
Neurodegenerative diseases
Neuroimaging
PET
dementia