Biomarkers for tau pathology

Schöll, Michael; Maass, Anne; Mattsson, Niklas; Ashton, Nicholas J.; Blennow, Kaj; Zetterberg, Henrik; Jagust, William

doi:10.1016/j.mcn.2018.12.001

Biomarkers for tau pathology

Journal Article · Fri Dec 07 00:00:00 EST 2018 · Molecular and cellular neurosciences

DOI:https://doi.org/10.1016/j.mcn.2018.12.001· OSTI ID:1623700

^[1]; Maass, Anne ^[2]; Mattsson, Niklas ^[3]; Ashton, Nicholas J. ^[4]; Blennow, Kaj ^[5]; Zetterberg, Henrik ^[6]; Jagust, William ^[7]

University of Gothenburg (Sweden); Lund University (Sweden); University College London (United Kingdom); OSTI
German Center for Neurodegenerative Diseases, Magdeburg (Germany); University of California, Berkeley, CA (United States)
Lund University (Sweden); Skåne University Hospital, Lund (Sweden)
University of Gothenburg (Sweden); King's College London (United Kingdom)
University of Gothenburg (Sweden); Sahlgrenska University Hospital, Mölndal (Sweden)
University College London (United Kingdom); University of Gothenburg (Sweden); Sahlgrenska University Hospital, Mölndal (Sweden); University College London (United Kingdom)
University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the development of methods to assess levels of tau protein in vivo in cerebrospinal fluid, which has significantly improved our knowledge about these conditions. Tau proteins have also been measured in blood, but the importance of tau-related changes in blood is still unclear. The recent addition of positron emission tomography ligands to visualize, map and quantify tau pathology has further contributed with information about the temporal and spatial characteristics of tau accumulation in the living brain. Together, the measurement of tau with fluid biomarkers and positron emission tomography constitutes the basis for a highly active field of research. This review describes the current state of biomarkers for tau biomarkers derived from neuroimaging and from the analysis of bodily fluids and their roles in the detection, diagnosis and prognosis of tau-associated neurodegenerative disorders, as well as their associations with neuropathological findings, and aims to provide a perspective on how these biomarkers might be employed prospectively in research and clinical settings.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: European Research Council; Knut and Alice Wallenberg Foundation; Sahlgrenska Academy; Swedish Alzheimer Foundation; Swedish Brain Foundation; Swedish Medical Association; Swedish Research Council; USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1623700

Journal Information:: Molecular and cellular neurosciences, Journal Name: Molecular and cellular neurosciences Journal Issue: C Vol. 97; ISSN 1044-7431

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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An autoradiographic evaluation of AV-1451 Tau PET in dementia Lowe, Val; Curran, Geoffry; Fang, Ping Figshare https://doi.org/10.6084/m9.figshare.c.3645467	collection	January 2016
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