Sizing up long non-coding RNAs: Do lncRNAs have secondary and tertiary structure?

Novikova, Irina V.; Hennelly, Scott P.; Sanbonmatsu, Karissa Y.

doi:10.4161/bioa.22592

Sizing up long non-coding RNAs: Do lncRNAs have secondary and tertiary structure?

Journal Article · Thu Nov 01 04:00:00 EDT 2012 · BioArchitecture

DOI:https://doi.org/10.4161/bioa.22592· OSTI ID:1629346

Novikova, Irina V. ^[1]; Hennelly, Scott P. ^[2]; Sanbonmatsu, Karissa Y. ^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States); DOE/OSTI
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Long noncoding RNAs (lncRNAs) play a key role in many important areas of epigenetics, stem cell biology, cancer, signaling and brain function. This emerging class of RNAs constitutes a large fraction of the transcriptome, with thousands of new lncRNAs reported each year. The molecular mechanisms of these RNAs are not well understood. Presently, very little structural data exist. We review the available lncRNA sequence and secondary structure data. Since almost no tertiary information is available for lncRNAs, we review crystallographic structures for other RNA systems and discuss the possibilities for lncRNAs in the context of existing constraints.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; USDOE Laboratory Directed Research and Development (LDRD) Program

OSTI ID:: 1629346

Journal Information:: BioArchitecture, Journal Name: BioArchitecture Journal Issue: 6 Vol. 2; ISSN 1949-0992

Publisher:: Taylor & FrancisCopyright Statement

Country of Publication:: United States

Language:: English

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The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers Goustin, Anton; Thepsuwan, Pattaraporn; Kosir, Mary Non-Coding RNA, Vol. 5, Issue 3 https://doi.org/10.3390/ncrna5030046	journal	September 2019

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59 BASIC BIOLOGICAL SCIENCES
HOTAIR
MALAT
RNA
RNA structure
cancer
epigenetics
hormone receptor
lincRNA
lncRNA
long noncoding RNA
non-coding
secondary structure
structural biology

Sizing up long non-coding RNAs: Do lncRNAs have secondary and tertiary structure?

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