Intrasubtype C superinfected individuals mount delayed and low-titer autologous neutralizing antibody responses prior to superinfection
- Emory Univ., Atlanta, GA (United States); DOE/OSTI
- Emory Univ., Atlanta, GA (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Zambia Emory HIV Research Project, Lusaka (Zambia)
- Emory Univ., Atlanta, GA (United States). Dept. of Global Health
The potential role of neutralizing antibody in protecting against intra-subtype HIV-1 superinfection remains to be understood. We compared the early neutralizing antibody responses in three individuals, who were superinfected within one year of primary infection, to ten case-matched non-superinfected controls from a Zambian cohort of subtype C transmission cases. Sequence analysis of single genome amplified full-length env showed minimal diversification in the individuals who became superinfected with the same subtype of HIV-1 within year one postseroconversion. We hypothesized that these superinfected individuals had a muted neutralizing antibody response that elicited little pressure on the founder virus to escape.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- Grant/Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1629285
- Journal Information:
- Retrovirology, Journal Name: Retrovirology Journal Issue: S2 Vol. 9; ISSN 1742-4690
- Publisher:
- BioMed CentralCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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