Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

Peck, Michael; Smith, Theresa; Anniballi, Fabrizio; Austin, John; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa; Derman, Yagmur; Dorner, Brigitte; Fisher, Audrey; Hill, Karen; Kalb, Suzanne; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Lúquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal; Stringer, Sandra

doi:10.3390/toxins9010038

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

Journal Article · Sat Dec 31 23:00:00 EST 2016 · Toxins

DOI:https://doi.org/10.3390/toxins9010038· OSTI ID:1628582

Peck, Michael ^[1]; Smith, Theresa ^[2]; Anniballi, Fabrizio ^[3]; Austin, John ^[4]; Bano, Luca ^[5]; Bradshaw, Marite ^[6]; Cuervo, Paula ^[7]; Cheng, Luisa ^[8]; Derman, Yagmur ^[9]; Dorner, Brigitte ^[10]; Fisher, Audrey ^[11]; Hill, Karen ^[12]; Kalb, Suzanne ^[13]; Korkeala, Hannu ^[9]; Lindström, Miia ^[9]; Lista, Florigio ^[14]; Lúquez, Carolina ^[15]; Mazuet, Christelle ^[16]; Pirazzini, Marco ^[17]; Popoff, Michel ^[16] more »

Inst. of Food Research, Norwich (United Kingdom); DOE/OSTI
US Army Medical Inst. of Infectious Diseases, Fort Detrick, MD (United States). Molecular and Translational Sciences Division
Istituto Superiore di Sanita, Rome (Italy). National Reference Centre for Botulism
Health Canada, Ottawa, ON (Canada). Bureau of Microbial Hazards
Istituto Zooprofilattico Sperimentale delle Venezie, Treviso (Italy)
Univ. of Wisconsin, Madison, WI (United States). Dept. of Bacteriology
Universidad Nacional de Cuyo, Mendoza (Argentina). Departamento de Patología. Área de Microbiología
US Dept. of Agriculture (USDA), Albany, CA (United States). Western Regional Research Center. Foodborne Toxin Detection and Prevention Research Unit
Univ. of Helsinki (Finland). Faculty of Veterinary Medicine. Dept. of Food Hygiene and Environmental Health
Robert Koch Inst., Berlin (Germany)
Johns Hopkins Univ., Baltimore, MD (United States). Applied Physics Lab.
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States). National Center for Environmental Health
Army Medical and Veterinary Research Center, Rome (Italy)
Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States). National Center for Emerging and Zoonotic Infectious Diseases
Institut Pasteur, Bactéries anaérobies et Toxines, Paris (France)
Univ. of Padova (Italy). Biomedical Sciences Dept.
Medizinische Hochschule Hannover, Hannover (Germany). Institut für Toxikologie
National Institute for Biological Standards and Control, Hertfordshire (United Kindgom). Centre of Medicines and Healthcare Products Regulatory Agency
Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA (United States)
Institute of Food Research, Norwich (United Kingdom)

Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1628582

Journal Information:: Toxins, Journal Name: Toxins Journal Issue: 1 Vol. 9; ISSN 2072-6651; ISSN TOXIB7

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy Fillo, Silvia; Giordani, Francesco; Anselmo, Anna Genome Announcements, Vol. 3, Issue 2 https://doi.org/10.1128/genomeA.00238-15	journal	March 2015
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59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
Clostridium botulinum
Food Science & Technology
Toxicology
botulinum
botulism
guidelines
neurotoxins
nomenclature
subtypes

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

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