Determinants of Organophosphorus Pesticide Urinary Metabolite Levels in Young Children Living in an Agricultural Community

Bradman, Asa; Castorina, Rosemary; Boyd Barr, Dana; Chevrier, Jonathan; Harnly, Martha E.; Eisen, Ellen A.; McKone, Thomas E.; Harley, Kim; Holland, Nina; Eskenazi, Brenda

doi:10.3390/ijerph8041061

Determinants of Organophosphorus Pesticide Urinary Metabolite Levels in Young Children Living in an Agricultural Community

Journal Article · Fri Apr 08 00:00:00 EDT 2011 · International Journal of Environmental Research and Public Health

DOI:https://doi.org/10.3390/ijerph8041061· OSTI ID:1628352

Bradman, Asa ^[1]; Castorina, Rosemary ^[2]; Boyd Barr, Dana ^[3]; Chevrier, Jonathan ^[2]; Harnly, Martha E. ^[4]; Eisen, Ellen A. ^[5]; McKone, Thomas E. ^[6]; Harley, Kim ^[2]; Holland, Nina ^[2]; Eskenazi, Brenda ^[2]

University of California, Berkeley, CA (United States); DOE/OSTI
University of California, Berkeley, CA (United States)
Emory University, Atlanta, GA (United States)
California Department of Public Health, Richmond, CA (United States)
University of California, Berkeley, CA (United States); Harvard School of Public Health, Boston, MA (United States)
University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Organophosphorus (OP) pesticides are used in agriculture and several are registered for home use. As young children age they may experience different pesticide exposures due to varying diet, behavior, and other factors. We measured six OP dialkylphosphate (DAP) metabolites (three dimethyl alkylphosphates (DMAP) and three diethyl alkylphosphates (DEAP)) in urine samples collected from ~400 children living in an agricultural community when they were 6, 12, and 24 months old. We examined bivariate associations between DAP metabolite levels and determinants such as age, diet, season, and parent occupation. To evaluate independent impacts, we then used generalized linear mixed multivariable models including interaction terms with age. The final models indicated that DMAP metabolite levels increased with age. DMAP levels were also positively associated with daily servings of produce at 6- and 24-months. Among the 6-month olds, DMAP metabolite levels were higher when samples were collected during the summer/spring versus the winter/fall months. Among the 12-month olds, DMAP and DEAP metabolites were higher when children lived ≤60 meters from an agricultural field. Among the 24-month-olds, DEAP metabolite levels were higher during the summer/spring months. Our findings suggest that there are multiple determinants of OP pesticide exposures, notably dietary intake and temporal and spatial proximity to agricultural use. The impact of these determinants varied by age and class of DAP metabolite.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628352

Journal Information:: International Journal of Environmental Research and Public Health, Journal Name: International Journal of Environmental Research and Public Health Journal Issue: 4 Vol. 8; ISSN IJERGQ; ISSN 1660-4601

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
agriculture
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