Comparison of Current-Use Pesticide and Other Toxicant Urinary Metabolite Levels among Pregnant Women in the CHAMACOS Cohort and NHANES

Journal Article · Wed Feb 03 00:00:00 EST 2010 · Environmental Health Perspectives

DOI:https://doi.org/10.1289/ehp.0901568· OSTI ID:1627103

Castorina, Rosemary ^[1]; Bradman, Asa ^[1]; Fenster, Laura ^[2]; Barr, Dana Boyd ^[3]; Bravo, Roberto ^[3]; Vedar, Michelle G. ^[1]; Harnly, Martha E. ^[2]; McKone, Thomas E. ^[4]; Eisen, Ellen A. ^[1]; Eskenazi, Brenda ^[1]

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1. University of California, Berkeley, CA (United States)
2. California Department of Public Health, Richmond, CA (United States)
3. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States)
4. University of California, Berkeley, CA (United States)University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

We measured 34 metabolites of current-use pesticides and other precursor compounds in urine samples collected twice during pregnancy from 538 women living in the Salinas Valley of California, a highly agricultural area (1999–2001). Precursors of these metabolites included fungicides, carbamate, organochlorine, organophosphorus (OP), and pyrethroid insecticides, and triazine and chloroacetanilide herbicides. We also measured ethylenethiourea, a metabolite of the ethylene-bisdithiocarbamate fungicides. Repeat measurements of the compounds presented here have not been reported in pregnant women previously. To understand the impact of the women’s regional environment on these findings, we compared metabolite concentrations from the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) cohort with U.S. national reference data for 342 pregnant women sampled by the National Health and Nutrition Examination Survey (1999–2002).The eight metabolites detected in > 50% of samples [2,4-dichlorophenol (2,4-DCP); 2,5- dichlorophenol (2,5-DCP); 1- and 2-naphthol; ortho-phenylphenol (ORTH); para-nitrophenol (PNP); 2,4,6-trichlorophenol (2,4,6-TCP); and 3,4,6-trichloro-2-pyridinol (TCPy)] may be related to home or agricultural pesticide use in the Salinas Valley, household products, and other sources of chlorinated phenols. More than 78% of women in this study had detectable levels of at least one of the OP pesticide-specific metabolites that we measured, and > 30% had two or more. The 95th percentile values of six of the most commonly detected (> 50%) compounds were significantly higher among the CHAMACOS women after controlling for age, race, socioeconomic status, and smoking [(2,4-DCP; 2,5-DCP; ORTH; PNP; 2,4,6-TCP; and TCPy); quantile regression p < 0.05]. Findings suggest that the CHAMACOS cohort has an additional burden of precursor pesticide exposure compared with the national sample, possibly from living and/or working in an agricultural area.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institute of Environmental Health Sciences (NIEHS); USEPA
• Grant/Contract Number: AC02-05CH11231; RO1 OH007400-04; PO1 ES009605; RD 83171001
• OSTI ID: 1627103
• Journal Information: Environmental Health Perspectives, Vol. 118, Issue 6; ISSN 0091-6765
• Publisher: National Institute of Environmental Health Sciences
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
59 BASIC BIOLOGICAL SCIENCES
ETU
exposure
NHANES
organophosphate
pesticides
pregnancy
prenatal
urinary metabolites
women