A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha

Flores-Sandoval, Eduardo; Eklund, D. Magnus; Bowman, John L.; Bomblies, Kirsten

doi:10.1371/journal.pgen.1005207

A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha

Journal Article · Thu May 28 00:00:00 EDT 2015 · PLoS Genetics

DOI:https://doi.org/10.1371/journal.pgen.1005207· OSTI ID:1627308

Flores-Sandoval, Eduardo ^[1]; Eklund, D. Magnus ^[2]; Bowman, John L. ^[3]; Bomblies, Kirsten

Monash Univ., Melbourne, VIC (Australia). School of Biological Sciences; DOE/OSTI
Monash Univ., Melbourne, VIC (Australia). School of Biological Sciences
Monash Univ., Melbourne, VIC (Australia). School of Biological Sciences; Uppsala Univ. (Sweden). Evolutionary Biology Centre. Dept. of Plant Ecology and Evolution

In land plants comparative genomics has revealed that members of basal lineages share a common set of transcription factors with the derived flowering plants, despite sharing few homologous structures. The plant hormone auxin has been implicated in many facets of development in both basal and derived lineages of land plants. We functionally characterized the auxin transcriptional response machinery in the liverwort Marchantia polymorpha, a member of the basal lineage of extant land plants. All components known from flowering plant systems are present in M. polymorpha, but they exist as single orthologs: a single MpTOPLESS (TPL) corepressor, a single MpTRANSPORT INHIBITOR RESPONSE 1 auxin receptor, single orthologs of each class of AUXIN RESPONSE FACTOR (ARF; MpARF1, MpARF2, MpARF3), and a single negative regulator AUXIN/INDOLE-3-ACETIC ACID (MpIAA). Phylogenetic analyses suggest this simple system is the ancestral condition for land plants. We experimentally demonstrate that these genes act in an auxin response pathway — chimeric fusions of the MpTPL corepressor with heterodimerization domains of MpARF1, MpARF2, or their negative regulator, MpIAA, generate auxin insensitive plants that lack the capacity to pattern and transition into mature stages of development. Our results indicate auxin mediated transcriptional regulation acts as a facilitator of branching, differentiation and growth, rather than acting to determine or specify tissues during the haploid stage of the M. polymorpha life cycle. We hypothesize that the ancestral role of auxin is to modulate a balance of differentiated and pluri- or totipotent cell states, whose fates are determined by interactions with combinations of unrelated transcription factors.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1627308

Journal Information:: PLoS Genetics, Journal Name: PLoS Genetics Journal Issue: 5 Vol. 11; ISSN 1553-7404

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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