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Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling

Journal Article · · PLoS Genetics
 [1];  [2];  [2];  [3];  [4]
  1. Stanford Univ., CA (United States). School of Medicine. Dept. of Developmental Biology; DOE/OSTI
  2. Stanford Univ., CA (United States). School of Medicine. Dept. of Developmental Biology
  3. Stanford Univ., CA (United States). School of Medicine. Dept. of Developmental Biology; Stanford Univ., CA (United States). Howard Hughes Medical Inst.
  4. Stanford Univ., CA (United States). School of Medicine. Dept. of Developmental Biology; Stanford Univ., CA (United States). Howard Hughes Medical Inst.; Stanford Univ., CA (United States). School of Medicine. Dept. of Medicine (Oncology)
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Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic α-cells. Although Drosophila CC cells have been regarded as developmental orthologues of pituitary gland, the genetic regulation of CC development is poorly understood. From a genetic screen, we identified multiple novel regulators of CC development, including Notch signaling factors. Our studies demonstrate that the disruption of Notch signaling can lead to the expansion of CC cells. Live imaging demonstrates localized emergence of extra precursor cells as the basis of CC expansion in Notch mutants. Contrary to a recent report, we unexpectedly found that CC cells originate from head mesoderm. We show that Tinman expression in head mesoderm is regulated by Notch signaling and that the combination of Daughterless and Tinman is sufficient for ectopic CC specification in mesoderm. Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism.
Research Organization:
Stanford Univ., CA (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
OSTI ID:
1627292
Journal Information:
PLoS Genetics, Journal Name: PLoS Genetics Journal Issue: 8 Vol. 7; ISSN 1553-7404
Publisher:
Public Library of ScienceCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (5)

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A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion journal August 2014
ADrosophilaLexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research journal October 2016
Regulation of insulin and adipokinetic hormone/glucagon production in flies journal August 2019
Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans journal March 2019

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59 BASIC BIOLOGICAL SCIENCES
Genetics & Heredity