Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit

Chai, Phing Chian; Liu, Zhong; Chia, William; Cai, Yu

doi:10.1371/journal.pbio.1001494

Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit

Journal Article · Tue Feb 26 04:00:00 EST 2013 · PLoS Biology (Online)

DOI:https://doi.org/10.1371/journal.pbio.1001494· OSTI ID:1627169

Chai, Phing Chian ^[1]; Liu, Zhong ^[2]; Chia, William ^[2]; Cai, Yu ^[2]

National University of Singapore (Singapore); DOE/OSTI
National University of Singapore (Singapore)

In Drosophila postembryonic neuroblasts, transition in gene expression programs of a cascade of transcription factors (also known as the temporal series) acts together with the asymmetric division machinery to generate diverse neurons with distinct identities and regulate the end of neuroblast proliferation. However, the underlying mechanism of how this ‘‘temporal series’’ acts during development remains unclear. Here, we show that Hh signaling in the postembryonic brain is temporally regulated; excess (earlier onset of) Hh signaling causes premature neuroblast cell cycle exit and underproliferation, whereas loss of Hh signaling causes delayed cell cycle exit and excess proliferation. Moreover, the Hh pathway functions downstream of Castor but upstream of Grainyhead, two components of the temporal series, to schedule neuroblast cell cycle exit. Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis.

Research Organization:: National University of Singapore (Singapore)

Sponsoring Organization:: Temasek Life Sciences Laboratory; Singapore Millennium Foundation; National Institutes of Health (NIH)

OSTI ID:: 1627169

Journal Information:: PLoS Biology (Online), Journal Name: PLoS Biology (Online) Journal Issue: 2 Vol. 11; ISSN 1545-7885

Publisher:: Public Library of Science

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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