Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence

Chell, James M.; Brand, Andrea H.

doi:10.1016/j.cell.2010.12.007

Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence

Journal Article · Thu Dec 23 04:00:00 EST 2010 · Cell

DOI:https://doi.org/10.1016/j.cell.2010.12.007· OSTI ID:1623640

Chell, James M. ^[1]; Brand, Andrea H. ^[2]

Univ. of Cambridge (United Kingdom); DOE/OSTI
Univ. of Cambridge (United Kingdom)

The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control.

Research Organization:: Univ. of Cambridge (United Kingdom)

Sponsoring Organization:: Wellcome Trust

OSTI ID:: 1623640

Journal Information:: Cell, Journal Name: Cell Journal Issue: 7 Vol. 143; ISSN 0092-8674

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

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