The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis

Ryan, Joseph F.; Burton, Patrick M.; Mazza, Maureen E.; Kwong, Grace K.; Mullikin, James C.; Finnerty, John R.

doi:10.1186/gb-2006-7-7-r64

The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis

Journal Article · Mon Jul 24 00:00:00 EDT 2006 · GenomeBiology.com

DOI:https://doi.org/10.1186/gb-2006-7-7-r64· OSTI ID:1626711

Ryan, Joseph F. ^[1]; Burton, Patrick M. ^[2]; Mazza, Maureen E. ^[3]; Kwong, Grace K. ^[3]; Mullikin, James C. ^[4]; Finnerty, John R. ^[3]

Boston University, MA (United States); DOE/OSTI
National Human Genome Research Institute, Bethesda, MD (United States); Boston University, MA (United States)
Boston University, MA (United States)
National Human Genome Research Institute, Bethesda, MD (United States)

Homeodomain transcription factors are key components in the developmental toolkits of animals. While this gene superclass predates the evolutionary split between animals, plants, and fungi, many homeobox genes appear unique to animals. The origin of particular homeobox genes may, therefore, be associated with the evolution of particular animal traits. Here we report the first near-complete set of homeodomains from a basal (diploblastic) animal. Phylogenetic analyses were performed on 130 homeodomains from the sequenced genome of the sea anemone Nematostella vectensis along with 228 homeodomains from human and 97 homeodomains from Drosophila. The Nematostella homeodomains appear to be distributed among established homeodomain classes in the following fashion: 72 ANTP class; one HNF class; four LIM class; five POU class; 33 PRD class; five SINE class; and six TALE class. For four of the Nematostella homeodomains, there is disagreement between neighbor-joining and Bayesian trees regarding their class membership. A putative Nematostella CUT class gene is also identified. The homeodomain superclass underwent extensive radiations prior to the evolutionary split between Cnidaria and Bilateria. Fifty-six homeodomain families found in human and/or fruit fly are also found in Nematostella, though seventeen families shared by human and fly appear absent in Nematostella. Homeodomain loss is also apparent in the bilaterian taxa: eight homeodomain families shared by Drosophila and Nematostella appear absent from human (CG13424, EMXLX, HOMEOBRAIN, MSXLX, NK7, REPO, ROUGH, and UNC4), and six homeodomain families shared by human and Nematostella appear absent from fruit fly (ALX, DMBX, DUX, HNF, POU1, and VAX).

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Human Genome Research Institute (NHGRI); National Institutes of Health (NIH); National Science Foundation (NSF); USDOE Office of Science (SC), Biological and Environmental Research (BER); World Drum Corps Hall of Fame

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1626711

Journal Information:: GenomeBiology.com, Journal Name: GenomeBiology.com Journal Issue: 7 Vol. 7; ISSN 1465-6906

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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