A role for a novel centrosome cycle in asymmetric cell division

Rusan, Nasser M.; Peifer, Mark

doi:10.1083/jcb.200612140

Title: A role for a novel centrosome cycle in asymmetric cell division

Journal Article · Mon Apr 02 00:00:00 EDT 2007 · Journal of Cell Biology

DOI:https://doi.org/10.1083/jcb.200612140· OSTI ID:1625143

Rusan, Nasser M. ^[1]; Peifer, Mark ^[1]

University of North Carolina, Chapel Hill, NC (United States)

Tissue stem cells play a key role in tissue maintenance. Drosophila melanogaster central brain neuroblasts are excellent models for stem cell asymmetric division. Earlier work showed that their mitotic spindle orientation is established before spindle formation. We investigated the mechanism by which this occurs, revealing a novel centrosome cycle. In interphase, the two centrioles separate, but only one is active, retaining pericentriolar material and forming a “dominant centrosome.” This centrosome acts as a microtubule organizing center (MTOC) and remains stationary, forming one pole of the future spindle. The second centriole is inactive and moves to the opposite side of the cell before being activated as a centrosome/MTOC. This is accompanied by asymmetric localization of Polo kinase, a key centrosome regulator. Disruption of centrosomes disrupts the high fidelity of asymmetric division. We propose a two-step mechanism to ensure faithful spindle positioning: the novel centrosome cycle produces a single interphase MTOC, coarsely aligning the spindle, and spindle–cortex interactions refine this alignment.

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Research Organization:: University of North Carolina, Chapel Hill, NC (United States)

Sponsoring Organization:: American Cancer Society; National Institutes of Health (NIH)

DOE Contract Number:: PF-06-108-CCG; GM67236

OSTI ID:: 1625143

Journal Information:: Journal of Cell Biology, Vol. 177, Issue 1; ISSN 0021-9525

Publisher:: Rockefeller University Press

Country of Publication:: United States

Language:: English

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