A Ras GTPase associated protein is involved in the phototropic and circadian photobiology responses in fungi

Polaino, Silvia; Villalobos-Escobedo, José M.; Shakya, Viplendra P.  S.; Miralles-Durán, Alejandro; Chaudhary, Suman; Sanz, Catalina; Shahriari, Mahdi; Luque, Eva M.; Eslava, Arturo P.; Corrochano, Luis M.; Herrera-Estrella, Alfredo; Idnurm, Alexander

doi:10.1038/srep44790

A Ras GTPase associated protein is involved in the phototropic and circadian photobiology responses in fungi

Journal Article · Tue Mar 21 00:00:00 EDT 2017 · Scientific Reports

DOI:https://doi.org/10.1038/srep44790· OSTI ID:1624898

Polaino, Silvia ^[1]; Villalobos-Escobedo, José M. ^[2]; Shakya, Viplendra P. S. ^[3]; Miralles-Durán, Alejandro ^[4]; Chaudhary, Suman ^[3]; Sanz, Catalina ^[5]; Shahriari, Mahdi ^[5]; Luque, Eva M. ^[4]; Eslava, Arturo P. ^[5]; Corrochano, Luis M. ^[4]; Herrera-Estrella, Alfredo ^[2]; Idnurm, Alexander ^[6]

Univ. of Missouri, Kansas City, MO (United States). School of Biological Sciences. Division of Cell Biology and Biophysics; DOE/OSTI
National Polytechnic Inst. (IPN), Guanajuato (Mexico). Centre for Research and Advanced Studies (CINVESTAV). Lab. Nacional de Genomica para la Biodiversidad
Univ. of Missouri, Kansas City, MO (United States). School of Biological Sciences. Division of Cell Biology and Biophysics
Univ. of Sevilla (Spain). Dept. de Genetica
Univ. de Salamanca (Spain). Dept. de Microbiologia y Genetica
Univ. of Missouri, Kansas City, MO (United States). School of Biological Sciences. Division of Cell Biology and Biophysics; Univ. of Melbourne (Australia). School of BioSciences

Light is an environmental signal perceived by most eukaryotic organisms and that can have major impacts on their growth and development. The MadC protein in the fungus Phycomyces blakesleeanus (Mucoromycotina) has been postulated to form part of the photosensory input for phototropism of the fruiting body sporangiophores, but the madC gene has remained unidentified since the 1960s when madC mutants were first isolated. In this study the madC gene was identified by positional cloning. All madC mutant strains contain loss-of-function point mutations within a gene predicted to encode a GTPase activating protein (GAP) for Ras. The madC gene complements the Saccharomyces cerevisiae Ras-GAP ira1 mutant and the encoded MadC protein interacts with P. blakesleeanus Ras homologs in yeast two-hybrid assays, indicating that MadC is a regulator of Ras signaling. Deletion of the homolog in the filamentous ascomycete Neurospora crassa affects the circadian clock output, yielding a pattern of asexual conidiation similar to a ras-1 mutant that is used in circadian studies in N. crassa. Thus, MadC is unlikely to be a photosensor, yet is a fundamental link in the photo responses from blue light perceived by the conserved White Collar complex with Ras signaling in two distantly-related filamentous fungal species.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1624898

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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