Genome Features and Biochemical Characteristics of a Robust, Fast Growing and Naturally Transformable Cyanobacterium Synechococcus elongatus PCC 11801 Isolated from India

Jaiswal, Damini; Sengupta, Annesha; Sohoni, Sujata; Sengupta, Shinjinee; Phadnavis, Ambarish G.; Pakrasi, Himadri B.; Wangikar, Pramod P.

doi:10.1038/s41598-018-34872-z

Genome Features and Biochemical Characteristics of a Robust, Fast Growing and Naturally Transformable Cyanobacterium Synechococcus elongatus PCC 11801 Isolated from India

Journal Article · Fri Nov 09 00:00:00 EST 2018 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-018-34872-z· OSTI ID:1624436

Jaiswal, Damini ^[1]; Sengupta, Annesha ^[2]; Sohoni, Sujata ^[2]; Sengupta, Shinjinee ^[3]; Phadnavis, Ambarish G. ^[2]; Pakrasi, Himadri B. ^[4]; Wangikar, Pramod P. ^[5]

Indian Inst. of Technology (IIT), Mumbai (India). Dept. of Chemical Engineering; DOE/OSTI
Indian Inst. of Technology (IIT), Mumbai (India). Dept. of Chemical Engineering
Indian Inst. of Technology (IIT), Mumbai (India). Dept. of Chemical Engineering; Indian Inst. of Technology (IIT), Mumbai (India). DBT-PAN IIT Centre for Bioenergy
Washington Univ., St. Louis, MO (United States). Dept. of Biology; Washington Univ., St. Louis, MO (United States). Dept. of Energy, Environmental and Chemical Engineering
Indian Inst. of Technology (IIT), Mumbai (India). Dept. of Chemical Engineering; Indian Inst. of Technology (IIT), Mumbai (India). DBT-PAN IIT Centre for Bioenergy; Indian Inst. of Technology (IIT), Mumbai (India). Dept. of Chemical Engineering; Indian Inst. of Technology (IIT), Mumbai (India). Wadhwani Research Centre for Bioenginering

Cyanobacteria provide an interesting platform for biotechnological applications due to their efficient photoautotrophic growth, amenability to genetic engineering and the ability to grow on non-arable land. An ideal industrial strain of cyanobacteria would need to be fast growing and tolerant to high levels of temperature, light, carbon dioxide, salt and be naturally transformable. In this study, we report Synechococcus elongatus PCC 11801, a strain isolated from India that fulfills these requirements. The physiological and biochemical characteristics of PCC 11801 under carbon and light-limiting conditions were investigated. PCC 11801 shows a doubling time of 2.3h, that is the fastest growth for any cyanobacteria reported so far under ambient CO2 conditions. Genome sequence of PCC 11801 shows genome identity of ~83% with its closest neighbors Synechococcus elongatus PCC 7942 and Synechococcus elongatus UTEX 2973. The unique attributes of PCC 11801 genome are discussed in light of the physiological characteristics that are needed in an industrial strain. The genome of PCC 11801 shows several genes that do not have homologs in neighbor strains PCC 7942 and UTEX 2973, some of which may be responsible for adaptation to various abiotic stresses. The remarkably fast growth rate of PCC 11801 coupled with its robustness and ease of genetic transformation makes it an ideal candidate for the photosynthetic production of fuels and chemicals.

View Accepted Manuscript (DOE)

Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0010687

OSTI ID:: 1624436

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 8; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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