Meconium microbiome associates with the development of neonatal jaundice

Journal Article · Sat Sep 01 00:00:00 EDT 2018 · Clinical and translational gastroenterology

DOI:https://doi.org/10.1038/s41424-018-0048-x· OSTI ID:1624034

Dong, Tianyu ^[1]; Chen, Ting ^[2]; White, Richard Allen ^[3]; Wang, Xu ^[4]; Hu, Weiyue ^[4]; Liang, Yali ^[5]; Zhang, Yuqing ^[4]; Lu, Chuncheng ^[4]; Chen, Minjian ^[4]; Aase, Heidi ^[6]; Xia, Yankai ^[4]

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1. Nanjing Univ. (China). School of Public Health, Inst. of Toxicology, State Key Lab. of Reproductive Medicine; Nanjing Univ. (China). School of Public Health, Key Lab. of Modern Toxicology of Ministry of Education; DOE/OSTI
2. Nanjing Maternity and Child Health Hospital, Nanjing (China). The Affiliated Obstetrics and Gynaecology Hospital with Nanjing Medical University, Nanjing Maternity and Child Health Care Inst.
3. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Fundamental and Computational Sciences Directorate
4. Nanjing Univ. (China). School of Public Health, Inst. of Toxicology, State Key Lab. of Reproductive Medicine; Nanjing Univ. (China). School of Public Health, Key Lab. of Modern Toxicology of Ministry of Education
5. Wannan Medical College, Wuhu (China). School of Public Health
6. Norwegian Inst. of Public Health, Oslo (Norway). Dept. of Child Development

Objective: Neonatal jaundice is a common disease that affects up to 60% of newborns. Gut microbiota mediated the excretion of bilirubin from the human body. However, the relationship between early gut microbiome and development of neonatal jaundice is not fully understood. Here we sought to characterize meconium microbiome of newborns and to clarify its association with risk of neonatal jaundice. Methods: We conducted a nested case–control study with 301 newborns providing meconium samples from 2014 to 2015. The main outcome was the development of neonatal jaundice at 42 day follow-up. 16S rRNA gene sequencing was performed to profile the meconium microbiome. LEfSe was employed to identify different features between control and case groups. Logistic regression was used to estimate the risk effect of early gut microbiome on neonatal jaundice. Results: Logistic regression models suggested that higher α-diversity was significantly associated with lower risk of jaundice in cesarean infants (OR 0.72, 95% CI 0.52–0.98), but not in infants born naturally. Higher relative abundance of Bifidobacterium pseudolongum in newborn meconium was significantly associated with lower risk of jaundice both in cesarean-born infants and in the total subjects (OR 0.24, 95% CI 0.07–0.68; OR 0.55, 95% CI 0.31–0.95, respectively). Spearman’s correlations showed that relative abundance of B. pseudolongum was significantly correlated with α-diversity (P < 0.01). Conclusion: Preventive and treatment methods implying early gut microbiome intervention could be promising for the management of neonatal jaundice.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: AC05-76RL01830
• OSTI ID: 1624034
• Journal Information: Clinical and translational gastroenterology, Journal Name: Clinical and translational gastroenterology Journal Issue: 9 Vol. 9; ISSN 2155-384X
• Publisher: Wolters Kluwer
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Gastroenterology &amp; Hepatology