Reconstituting ring-rafts in bud-mimicking topography of model membranes

Ryu, Yong-Sang; Lee, In-Ho; Suh, Jeng-Hun; Park, Seung Chul; Oh, Soojung; Jordan, Luke R.; Wittenberg, Nathan J.; Oh, Sang-Hyun; Jeon, Noo Li; Lee, Byoungho; Parikh, Atul N.; Lee, Sin-Doo

doi:10.1038/ncomms5507

Reconstituting ring-rafts in bud-mimicking topography of model membranes

Journal Article · Thu Jul 24 00:00:00 EDT 2014 · Nature Communications

DOI:https://doi.org/10.1038/ncomms5507· OSTI ID:1623953

Ryu, Yong-Sang ^[1]; Lee, In-Ho ^[2]; Suh, Jeng-Hun ^[2]; Park, Seung Chul ^[2]; Oh, Soojung ^[3]; Jordan, Luke R. ^[4]; Wittenberg, Nathan J. ^[5]; Oh, Sang-Hyun ^[6]; Jeon, Noo Li ^[3]; Lee, Byoungho ^[2]; Parikh, Atul N. ^[7]; Lee, Sin-Doo ^[2]

Seoul National Univ. (Korea, Republic of). School of Electrical Engineering; DOE/OSTI
Seoul National Univ. (Korea, Republic of). School of Electrical Engineering
Seoul National Univ. (Korea, Republic of). School of Mechanical and Aerospace Engineering. World Class Univ. (WCU) Program of Multiscale Mechanical Design
Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Biomedical Engineering
Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Biomedical Engineering and Chemical Engineering and Materials Science
Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Biomedical Engineering; Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Biomedical Engineering and Chemical Engineering and Materials Science
Univ. of California, Davis, CA (United States). Dept. of Biomedical Engineering and Chemical Engineering and Materials Science; Nanyang Technological Univ. (Singapore). School of Materials Science and Engineering. Centre for Biomimetic Sensor Science

During vesicular trafficking and release of enveloped viruses, the budding and fission processes dynamically remodel the donor cell membrane in a protein- or a lipid-mediated manner. In all cases, in addition to the generation or relief of the curvature stress, the buds recruit specific lipids and proteins from the donor membrane through restricted diffusion for the development of a ring-type raft domain of closed topology. Here, by reconstituting the bud topography in a model membrane, we demonstrate the preferential localization of cholesterol- and sphingomyelin-enriched microdomains in the collar band of the bud-neck interfaced with the donor membrane. The geometrical approach to the recapitulation of the dynamic membrane reorganization, resulting from the local radii of curvatures from nanometre-to-micrometre scales, offers important clues for understanding the active roles of the bud topography in the sorting and migration machinery of key signalling proteins involved in membrane budding.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of California, Davis, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-04ER46173

OSTI ID:: 1623953

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 5; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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