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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Journal Article · · Nature Communications
DOI:https://doi.org/10.1038/ncomms15451· OSTI ID:1623892
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  1. Univ. of New Mexico, Albuquerque, NM (United States). Center for Theoretical and Evolutionary Immunology; DOE/OSTI
  2. Washington Univ., St. Louis, MO (United States). The McDonnell Genome Inst.
  3. Univ. of Aberdeen (United Kingdom). School of Biological Sciences. Inst. of Biological and Environmental Sciences
  4. Univ. of New Mexico, Albuquerque, NM (United States). Center for Theoretical and Evolutionary Immunology
  5. George Washington Univ., Washington, DC (United States). School of Medicine & Health Sciences. Research Center for Neglected Diseases of Poverty. Dept. of Microbiology, Immunology & Tropical Medicine; Univ. of the District of Columbia, Washington, DC (United States). Division of Science & Mathematics
  6. FIOCRUZ-Minas, Minas Gerais (Brazil). Rene Rachou Research Center; Instituto Tecnolo´gico Vale, Belem (Brazil)
  7. Silver Spring, MD
  8. College of Charleston, SC (United States). Medical University of South Carolina College of Graduate Studies Hollings Marine Laboratory Charleston. Biology Dept.
  9. Federal University of Uberlandia - Campus Patos de Minas (UFU), CEP, Patos de Minas (Brazil). Inst. of Genetics and Biochemistry. Lab. of Bioinformatics and Molecular Analysis
  10. Brunel Univ., Middlesex (United Kingdom). College of Health and Life Sciences. Dept. of Life Sciences
  11. FIOCRUZ-Minas, Minas Gerais (Brazil). Rene Rachou Research Center
  12. Inst. Minoru de Recherche Avancee (IMRA), Sophia Antipolis, Cedex (France). Instiut Sophia Agrobiotech. INRA/CNRS/UNS
  13. Oregon State Univ., Corvallis, OR (United States). Dept. of Integrative Biology
  14. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Dept. of Pathobiological Sciences
  15. Carleton Univ., Ottawa, ON (Canada). Inst. of Biochemistry. Dept. of Biology
  16. Iowa State Univ., Ames, IA (United States)
  17. Harvard Medical School, Boston, MA (United States). Dept. of Information Technology
  18. Univ. of Toronto, ON (Canada). Sunnybrook Health Sciences Centre. Dept. of Immunology
  19. FIOCRUZ-Minas, Rene´ Rachou Research Center, Belo Horizonte (Brazil). Laboratorio de Helmintologia e Malacologia Medica
  20. Univ. of Utah, Salt Lake City, UT (United States). Dept. of Human Genetics
  21. New Mexico State Univ., Las Cruces, NM (United States). Dept. of Biology
  22. Aberystwyth Univ. (United Kingdom). IBERS. Animal and Microbial Sciences Research Theme
  23. Wellcome Genome Campus, Cambridgeshire (United Kingdom). EMBL-EBI
  24. Montpellier Univ. 2 (France)
  25. Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Biology
  26. Univ. of the Sunshine Coast, Queensland (Australia). Faculty of Science, Health and Education
  27. The Walter and Eliza Hall Inst. for Medical Research, Victoria (Australia); Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli, Melanoma Research Fellow Peter MacCallum Cancer Centre, Victoria (Australia)
  28. Univ. of Notre Dame, IN (United States). Genomics and Bioinformatics Core Facility
  29. Univ. of Copenhagen (Denmark). Faculty of Science. Dept. of Plant and Environmental Sciences
  30. National Inst. of Health (NIH), Bethesda, MD (United States). National Cancer Inst. Genome Analysis Unit
  31. Washington Univ., St. Louis, MO (United States). The McDonnell Genome Inst
  32. FIOCRUZ-Minas, Minas Gerais (Brazil). Rene Rachou Research Cente
  33. Bowling Green State Univ., OH (United States). Biological Sciences
  34. Univ. of Alberta, Edmonton, AB (Canada). Dept. of Public Health Sciences
  35. Lawrence Univ., Appleton, WI (United States). Dept. of Biology
  36. Georg-August Univ. of Gottingen (Germany). Courant Research Centre Geobiology
  37. Brunel Univ., Middlesex (United Kingdom). Inst. of Environment, Health and Societies. Environment and Health Theme
  38. Pennsylvania State Univ., University Park, PA (United States). Dept. of Biology
  39. Vrije Univ., Amsterdam (Netherlands). Facultiet de Aard-en Levenswetenschappen
  40. Univ. of Florida, Saint Augustine, FL (United States). The Whitney Lab. for Marine Bioscience
  41. Kingston Univ., Surry (United Kingdom). Molecular Parasitology Lab. School of Life Sciences Pharmacy and Chemistry
  42. QIMR Berghofer Medical Research Institute, Brisbane (Australia). Molecular Parasitology Lab.
  43. Kenya Medical Research Inst., Nairobi (Kenya)
  44. Univ. of Pennsylvania, Philadelphia, PA (United States). Perelman School of Medicine. Dept. of Neuroscience
  45. Univ. of Florida, Saint Augustine, FL (United States). The Whitney Lab for Marine Bioscience
  46. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Genomics and Systems Biology Division. Berkeley Bioinformatics Open-Source Projects
  47. Aberystwyth Univ. (United Kingdom). Animal and Microbial Science Research Theme
  48. The Walter and Eliza Hall Inst. for Medical Research, Victoria (Australia)
  49. Carleton Univ., Ottawa, ON (Canada). Dept. of Systems and Computer Engineering
  50. Univ. of Alberta, Edmonton, AB (Canada). Dept. of Public Health
  51. Univ. of California, Santa Cruz, CA (United States). Genomics Inst.
  52. London Centre for Neglected Tropical Disease Research, London (United Kingdom). Wolfson Wellcome Biomedical Labs. Parasites and Vectors Division
  53. Aberystwyth Univ. (United Kingdom). Animal and Microbial Sciences Research Theme
  54. Univ. of Westminster, London (United Kingdom). Faculty of Science and Technology. Dept. of Biomedical Sciences
  55. Kingston Univ., Surrey (United Kingdom). School og Life Sciences Pharmacy and Chemistry. Molecular Parasitology Lab.
  56. George Washington Univ., Washington, DC (United States). School of Medicine and Health Sciences. Research Center for Neglected Diseases of Poverty. Dept. of Microbiology, Immunology and Tropical Medicine
  57. Univ. of Wisconsin, Madison, WI (United States). Dept. of Pathobiological Sciences
  58. Univ. College London (United Kingdom). London Centre for Nanotechnology; Rutheford Appleton Lab., Oxford (United Kingdom). Research Complex at Harwell
+ Show Author Affiliations
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization’s goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1623892
Journal Information:
Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 8; ISSN 2041-1723
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (45)

Transcriptome sequencing and differential gene expression analysis of the schistosome-transmitting snail Oncomelania hupensis inhabiting hilly and marshland regions journal November 2017
Complete mitochondrial and rDNA complex sequences of important vector species of Biomphalaria, obligatory hosts of the human-infecting blood fluke, Schistosoma mansoni journal May 2018
A draft genome assembly of the solar-powered sea slug Elysia chlorotica journal February 2019
Signatures of Divergence, Invasiveness, and Terrestrialization Revealed by Four Apple Snail Genomes journal April 2019
Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata posted_content September 2019
Correction to: Sequence and structural variation in the genome of the Biomphalaria glabrata embryonic (Bge) cell line journal October 2018
Central nervous system transcriptome of Biomphalaria alexandrina, an intermediate host for schistosomiasis journal December 2017
Regulation of fiber-specific actin expression by the Drosophila SRF ortholog Blistered journal March 2019
Comparative genomics of bdelloid rotifers: Insights from desiccating and nondesiccating species journal April 2018
A Targeted Capture Linkage Map Anchors the Genome of the Schistosomiasis Vector Snail, Biomphalaria glabrata journal May 2017
Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals journal July 2018
Biomphalaria glabrata Granulin Increases Resistance to Schistosoma mansoni Infection in Several Biomphalaria Species and Induces the Production of Reactive Oxygen Species by Haemocytes journal December 2019
Challenging the Metallothionein (MT) Gene of Biomphalaria glabrata: Unexpected Response Patterns Due to Cadmium Exposure and Temperature Stress journal August 2017
Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection journal August 2018
Additional file 1 of Core gut microbes Cloacibacterium and Aeromonas associated with different gastropod species could be persistently transmitted across multiple generations dataset January 2023
Molluscan genomics: the road so far and the way forward journal November 2019
Identification and sequencing of the gene encoding DNA methyltransferase 3 (DNMT3) from sea cucumber, Apostichopus japonicus journal April 2019
Molluscan Genomics: Implications for Biology and Aquaculture journal October 2017
A chromosomal-level genome assembly for the giant African snail Achatina fulica journal October 2019
Evolutionary Origins of Toll-like Receptor Signaling journal March 2018
Studying 3D cell cultures in a microfluidic droplet array under multiple time-resolved conditions posted_content September 2018
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The effect of mating on female reproduction across hermaphroditic freshwater snails journal January 2020
Genome-wide discovery, and computational and transcriptional characterization of an AIG gene family in the freshwater snail Biomphalaria glabrata, a vector for Schistosoma mansoni journal March 2020
Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection journal June 2017
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A Biomphalaria glabrata peptide that stimulates significant behaviour modifications in aquatic free-living Schistosoma mansoni miracidia journal January 2019
The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata journal September 2019
Gene drives for schistosomiasis transmission control journal December 2019
Differential expression of small RNA pathway genes associated with the Biomphalaria glabrata/Schistosoma mansoni interaction journal July 2017
Comparative genomics of bdelloid rotifers: Insights from desiccating and nondesiccating species. text January 2018
Gene drives for schistosomiasis transmission control text January 2019
Glabralysins, Potential New β-Pore-Forming Toxin Family Members from the Schistosomiasis Vector Snail Biomphalaria glabrata journal January 2020
A New Assessment of Thioester-Containing Proteins Diversity of the Freshwater Snail Biomphalaria glabrata journal January 2020
A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire Snail Cumia reticulata journal February 2019
Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata journal January 2020

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