Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin

Hemmatian, Zahra; Keene, Scott; Josberger, Erik; Miyake, Takeo; Arboleda, Carina; Soto-Rodríguez, Jessica; Baneyx, François; Rolandi, Marco

doi:10.1038/ncomms12981

Electronic control of H⁺ current in a bioprotonic device with Gramicidin A and Alamethicin

Journal Article · Fri Oct 07 00:00:00 EDT 2016 · Nature Communications

DOI:https://doi.org/10.1038/ncomms12981· OSTI ID:1623853

Hemmatian, Zahra ^[1]; Keene, Scott ^[2]; Josberger, Erik ^[3]; Miyake, Takeo ^[4]; Arboleda, Carina ^[2]; Soto-Rodríguez, Jessica ^[5]; Baneyx, François ^[5]; Rolandi, Marco ^[4]

Univ. of California, Santa Cruz, CA (United States). Dept. of Electrical Engineering; Univ. of Washington, Seattle, WA (United States). Dept. of Materials Science and Engineering; DOE/OSTI
Univ. of Washington, Seattle, WA (United States). Dept. of Materials Science and Engineering
Univ. of Washington, Seattle, WA (United States). Dept. of Materials Science and Engineering; Univ. of Washington, Seattle, WA (United States). Dept of Electrical Engineering
Univ. of California, Santa Cruz, CA (United States). Dept. of Electrical Engineering; Univ. of Washington, Seattle, WA (United States). Dept. of Materials Science and Engineering
Univ. of Washington, Seattle, WA (United States). Dept. of Chemical Engineering

In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic–abiotic bioprotonic device with Pd contacts that regulates proton (H⁺) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman–Hodgkin–Katz (GHK) solution to the Nernst–Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H⁺ channels at the Pd contact interface to produce responsive biotic–abiotic devices with increased functionality.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Washington, Seattle, WA (United States)

Sponsoring Organization:: National Institutes of Health; National Science Foundation; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0010441

OSTI ID:: 1623853

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 7; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

References (75)

A Biomimetic Composite from Solution Self-Assembly of Chitin Nanofibers in a Silk Fibroin Matrix Jin, Jungho; Hassanzadeh, Pegah; Perotto, Giovanni Advanced Materials, Vol. 25, Issue 32 https://doi.org/10.1002/adma.201301429	journal	June 2013
Two-Terminal Protonic Devices with Synaptic-Like Short-Term Depression and Device Memory Josberger, Erik E.; Deng, Yingxin; Sun, Wei Advanced Materials, Vol. 26, Issue 29 https://doi.org/10.1002/adma.201400320	journal	May 2014
Highly Skin-Conformal Microhairy Sensor for Pulse Signal Amplification Pang, Changhyun; Koo, Ja Hoon; Nguyen, Amanda Advanced Materials, Vol. 27, Issue 4 https://doi.org/10.1002/adma.201403807	journal	October 2014
Organic Bioelectronic Materials and Devices Malliaras, George; Abidian, Mohammad Reza Advanced Materials, Vol. 27, Issue 46 https://doi.org/10.1002/adma.201504783	journal	December 2015
A Palladium-Binding Deltarhodopsin for Light-Activated Conversion of Protonic to Electronic Currents Soto-Rodríguez, Jessica; Hemmatian, Zahra; Josberger, Erik E. Advanced Materials, Vol. 28, Issue 31 https://doi.org/10.1002/adma.201600222	journal	May 2016
A kinetic study of vesicle fusion on silicon dioxide surfaces by ellipsometry Stroumpoulis, Dimitrios; Parra, Alejandro; Tirrell, Matthew AIChE Journal, Vol. 52, Issue 8 https://doi.org/10.1002/aic.10914	journal	January 2006
Model ion channels: Gramicidin and alamethicin Andrew Woolley, G.; Wallace, B. A. The Journal of Membrane Biology, Vol. 129, Issue 2 https://doi.org/10.1007/bf00219508	journal	August 1992
Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin Bechinger, B. Journal of Membrane Biology, Vol. 156, Issue 3 https://doi.org/10.1007/s002329900201	journal	April 1997
Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports Kowal, Justyna Ł.; Kowal, Julia K.; Wu, Dalin Biomaterials, Vol. 35, Issue 26 https://doi.org/10.1016/j.biomaterials.2014.05.043	journal	August 2014
Voltage-dependent energetics of alamethicin monomers in the membrane Mottamal, Madhusoodanan; Lazaridis, Themis Biophysical Chemistry, Vol. 122, Issue 1 https://doi.org/10.1016/j.bpc.2006.02.005	journal	June 2006
Solid supported lipid bilayers: From biophysical studies to sensor design Castellana, Edward T.; Cremer, Paul S. Surface Science Reports, Vol. 61, Issue 10 https://doi.org/10.1016/j.surfrep.2006.06.001	journal	November 2006
Supported planar bilayer formation by vesicle fusion: the interaction of phospholipid vesicles with surfaces and the effect of gramicidin on bilayer properties using atomic force microscopy Leonenko, Z. V.; Carnini, A.; Cramb, D. T. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1509, Issue 1-2 https://doi.org/10.1016/s0005-2736(00)00288-1	journal	December 2000
Supported phospholipid bilayers Tamm, L. K.; McConnell, H. M. Biophysical Journal, Vol. 47, Issue 1 https://doi.org/10.1016/s0006-3495(85)83882-0	journal	January 1985
Structure of an adsorbed dimyristoylphosphatidylcholine bilayer measured with specular reflection of neutrons Johnson, S. J.; Bayerl, T. M.; McDermott, D. C. Biophysical Journal, Vol. 59, Issue 2 https://doi.org/10.1016/s0006-3495(91)82222-6	journal	February 1991
Polymer-Cushioned Bilayers. I. A Structural Study of Various Preparation Methods Using Neutron Reflectometry Wong, J. Y.; Majewski, J.; Seitz, M. Biophysical Journal, Vol. 77, Issue 3 https://doi.org/10.1016/s0006-3495(99)76992-4	journal	September 1999
Membrane channel-forming polypeptides. Aqueous phase aggregation and membrane-modifying activity of synthetic fluorescent alamethicin fragments. Mathew, M. K.; Nagaraj, R.; Balaram, P. Journal of Biological Chemistry, Vol. 257, Issue 5 https://doi.org/10.1016/s0021-9258(18)34901-9	journal	March 1982
Bacterial flagellar motor and H+/ATP synthase: two proton-driven rotary molecular devices with different functions Walz, Dieter; Caplan, S. Roy Bioelectrochemistry, Vol. 55, Issue 1-2 https://doi.org/10.1016/s1567-5394(01)00162-1	journal	January 2002
Anion Transport through Lipids in a Hybrid Bilayer Membrane Tse, Edmund C. M.; Barile, Christopher J.; Gewargis, John P. Analytical Chemistry, Vol. 87, Issue 4 https://doi.org/10.1021/ac5043544	journal	February 2015
The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma DeCoursey, Thomas E. Biochemistry, Vol. 54, Issue 21 https://doi.org/10.1021/acs.biochem.5b00353	journal	May 2015
Effect of Modified Phospholipid Bilayers on the Electrochemical Activity of a Membrane-Spanning Conjugated Oligoelectrolyte Jahnke, Justin P.; Bazan, Guillermo C.; Sumner, James J. Langmuir, Vol. 31, Issue 42 https://doi.org/10.1021/acs.langmuir.5b03093	journal	July 2015
Proton conduction and injection in solids Glasser, L. Chemical Reviews, Vol. 75, Issue 1 https://doi.org/10.1021/cr60293a002	journal	February 1975
Double Cushions Preserve Transmembrane Protein Mobility in Supported Bilayer Systems Diaz, Arnaldo J.; Albertorio, Fernando; Daniel, Susan Langmuir, Vol. 24, Issue 13 https://doi.org/10.1021/la800018d	journal	July 2008
Formation, Stability, and Mobility of One-Dimensional Lipid Bilayers on Polysilicon Nanowires Huang, Shih-Chieh J.; Artyukhin, Alexander B.; Martinez, Julio A. Nano Letters, Vol. 7, Issue 11 https://doi.org/10.1021/nl071641w	journal	November 2007
Carbon Nanotube Transistor Controlled by a Biological Ion Pump Gate Huang, Shih-Chieh J.; Artyukhin, Alexander B.; Misra, Nipun Nano Letters, Vol. 10, Issue 5 https://doi.org/10.1021/nl100499x	journal	May 2010
Bulk protonic conductivity in a cephalopod structural protein Ordinario, David D.; Phan, Long; Walkup IV, Ward G. Nature Chemistry, Vol. 6, Issue 7 https://doi.org/10.1038/nchem.1960	journal	June 2014
A polysaccharide bioprotonic field-effect transistor Zhong, Chao; Deng, Yingxin; Roudsari, Anita Fadavi Nature Communications, Vol. 2, Issue 1 https://doi.org/10.1038/ncomms1489	journal	September 2011
Logic gates based on ion transistors Tybrandt, Klas; Forchheimer, Robert; Berggren, Magnus Nature Communications, Vol. 3, Issue 1 https://doi.org/10.1038/ncomms1869	journal	January 2012
Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity Watanabe, Rikiya; Soga, Naoki; Fujita, Daishi Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5519	journal	July 2014
Formation of artificial lipid bilayers using droplet dielectrophoresis Aghdaei, Sara; Sandison, Mairi E.; Zagnoni, Michele Lab on a Chip, Vol. 8, Issue 10 https://doi.org/10.1039/b807374k	journal	January 2008
Taking electrons out of bioelectronics: bioprotonic memories, transistors, and enzyme logic Hemmatian, Zahra; Miyake, Takeo; Deng, Yingxin Journal of Materials Chemistry C, Vol. 3, Issue 25 https://doi.org/10.1039/c5tc00502g	journal	January 2015
Protonic transistors from thin reflectin films Ordinario, David D.; Phan, Long; Jocson, Jonah-Micah APL Materials, Vol. 3, Issue 1 https://doi.org/10.1063/1.4901296	journal	January 2015
Bioelectronic silicon nanowire devices using functional membrane proteins Misra, N.; Martinez, J. A.; Huang, S. -C. J. Proceedings of the National Academy of Sciences, Vol. 106, Issue 33 https://doi.org/10.1073/pnas.0904850106	journal	August 2009
Ion bipolar junction transistors Tybrandt, K.; Larsson, K. C.; Richter-Dahlfors, A. Proceedings of the National Academy of Sciences, Vol. 107, Issue 22 https://doi.org/10.1073/pnas.0913911107	journal	May 2010
Voltage-gated proton channel in a dinoflagellate Smith, S. M. E.; Morgan, D.; Musset, B. Proceedings of the National Academy of Sciences, Vol. 108, Issue 44 https://doi.org/10.1073/pnas.1115405108	journal	October 2011
Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors Angione, M. D.; Cotrone, S.; Magliulo, M. Proceedings of the National Academy of Sciences, Vol. 109, Issue 17 https://doi.org/10.1073/pnas.1200549109	journal	April 2012
Grotthuss mechanisms: from proton transport in proton wires to bioprotonic devices Miyake, Takeo; Rolandi, Marco Journal of Physics: Condensed Matter, Vol. 28, Issue 2 https://doi.org/10.1088/0953-8984/28/2/023001	journal	December 2015
The effect of sodium ions on the electrical activity of the giant axon of the squid Hodgkin, A. L.; Katz, B. The Journal of Physiology, Vol. 108, Issue 1 https://doi.org/10.1113/jphysiol.1949.sp004310	journal	March 1949
Therapy using implanted organic bioelectronics Jonsson, Amanda; Song, Zhiyang; Nilsson, David Science Advances, Vol. 1, Issue 4 https://doi.org/10.1126/sciadv.1500039	journal	May 2015
Electronic plants Stavrinidou, Eleni; Gabrielsson, Roger; Gomez, Eliot Science Advances, Vol. 1, Issue 10 https://doi.org/10.1126/sciadv.1501136	journal	November 2015
Electrophysiological Characterization of Membrane Transport Proteins Grewer, Christof; Gameiro, Armanda; Mager, Thomas Annual Review of Biophysics, Vol. 42, Issue 1 https://doi.org/10.1146/annurev-biophys-083012-130312	journal	May 2013
Bacteriorhodopsin Lanyi, Janos K. Annual Review of Physiology, Vol. 66, Issue 1 https://doi.org/10.1146/annurev.physiol.66.032102.150049	journal	March 2004
Investigation of Temperature-Induced Phase Transitions in DOPC and DPPC Phospholipid Bilayers Using Temperature-Controlled Scanning Force Microscopy Leonenko, Z. V.; Finot, E.; Ma, H. Biophysical Journal, Vol. 86, Issue 6 https://doi.org/10.1529/biophysj.103.036681	journal	June 2004
Following the Formation of Supported Lipid Bilayers on Mica: A Study Combining AFM, QCM-D, and Ellipsometry Richter, Ralf P.; Brisson, Alain R. Biophysical Journal, Vol. 88, Issue 5 https://doi.org/10.1529/biophysj.104.053728	journal	May 2005
Preparation of DOPC and DPPC Supported Planar Lipid Bilayers for Atomic Force Microscopy and Atomic Force Spectroscopy Attwood, Simon; Choi, Youngjik; Leonenko, Zoya International Journal of Molecular Sciences, Vol. 14, Issue 2 https://doi.org/10.3390/ijms14023514	journal	February 2013
Crossing Over: Nanostructures that Move Electrons and Ions across Cellular Membranes Ajo-Franklin, Caroline M.; Noy, Aleksandr Advanced Materials, Vol. 27, Issue 38 https://doi.org/10.1002/adma.201500344	journal	April 2015
Epilepsy Treatment: Controlling Epileptiform Activity with Organic Electronic Ion Pumps (Adv. Mater. 20/2015) Williamson, Adam; Rivnay, Jonathan; Kergoat, Loïg Advanced Materials, Vol. 27, Issue 20 https://doi.org/10.1002/adma.201570133	journal	May 2015
Induction of a Proton Gradient across a Gold-Supported Biomimetic Membrane by Electroenzymatic H ₂ Oxidation Gutiérrez-Sanz, Óscar; Tapia, Cristina; Marques, Marta C. Angewandte Chemie International Edition, Vol. 54, Issue 9 https://doi.org/10.1002/anie.201411182	journal	January 2015
What Do Neutrons, X-ray Synchrotron Radiation, Optical ph-indicators, and Mutagenesis Tell us About the Light-driven Proton Pump Bacteriorhodopsin? Dencher, Norbert A.; Heberle, Joachim; Büldt, Georg The Jerusalem Symposia on Quantum Chemistry and Biochemistry https://doi.org/10.1007/978-94-011-2718-9_7	book	January 1992
Alamethicin pore formation: Voltage-dependent flip-flop of ?-helix dipoles Boheim, G.; Hanke, W.; Jung, G. Biophysics of Structure and Mechanism, Vol. 9, Issue 3 https://doi.org/10.1007/BF00537815	journal	January 1983
Supported planar bilayer formation by vesicle fusion: the interaction of phospholipid vesicles with surfaces and the effect of gramicidin on bilayer properties using atomic force microscopy Leonenko, Z. V.; Carnini, A.; Cramb, D. T. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1509, Issue 1-2 https://doi.org/10.1016/S0005-2736(00)00288-1	journal	December 2000
Supported phospholipid bilayers Tamm, L. K.; McConnell, H. M. Biophysical Journal, Vol. 47, Issue 1 https://doi.org/10.1016/S0006-3495(85)83882-0	journal	January 1985
Structure of an adsorbed dimyristoylphosphatidylcholine bilayer measured with specular reflection of neutrons Johnson, S. J.; Bayerl, T. M.; McDermott, D. C. Biophysical Journal, Vol. 59, Issue 2 https://doi.org/10.1016/S0006-3495(91)82222-6	journal	February 1991
Polymer-Cushioned Bilayers. I. A Structural Study of Various Preparation Methods Using Neutron Reflectometry Wong, J. Y.; Majewski, J.; Seitz, M. Biophysical Journal, Vol. 77, Issue 3 https://doi.org/10.1016/S0006-3495(99)76992-4	journal	September 1999
Membrane channel-forming polypeptides. Aqueous phase aggregation and membrane-modifying activity of synthetic fluorescent alamethicin fragments. Mathew, M. K.; Nagaraj, R.; Balaram, P. Journal of Biological Chemistry, Vol. 257, Issue 5 https://doi.org/10.1016/S0021-9258(18)34901-9	journal	March 1982
Kinetics of bulk and interfacial ionic motion: microscopic bases and limits for the nernst—planck equation applied to membrane systems Buck, Richard P. Journal of Membrane Science, Vol. 17, Issue 1 https://doi.org/10.1016/S0376-7388(00)81386-1	journal	January 1984
Molecular transport and organization in supported lipid membranes Boxer, S. Current Opinion in Chemical Biology, Vol. 4, Issue 6 https://doi.org/10.1016/S1367-5931(00)00139-3	journal	December 2000
Analytical model of the anode side of DMFC: the effect of non-Tafel kinetics on cell performance Kulikovsky, A. A. Electrochemistry Communications, Vol. 5, Issue 7 https://doi.org/10.1016/S1388-2481(03)00115-2	journal	July 2003
Bacterial flagellar motor and H+/ATP synthase: two proton-driven rotary molecular devices with different functions Walz, Dieter; Caplan, S. Roy Bioelectrochemistry, Vol. 55, Issue 1-2 https://doi.org/10.1016/S1567-5394(01)00162-1	journal	January 2002
Mimicking Biology with Nanomaterials: Carbon Nanotube Porins in Lipid Membranes Noy, Aleksandr Biophysical Journal, Vol. 108, Issue 2 https://doi.org/10.1016/j.bpj.2014.11.2418	journal	January 2015
Bio-Inspired pH Responsive Hydrogels for Programmed Activation of Electrochemical Storage Systems in Biology Johnson, Nateé; Kim, Young Jo; Dingh, Hangjun Biophysical Journal, Vol. 108, Issue 2 https://doi.org/10.1016/j.bpj.2014.11.2653	journal	January 2015
Biomimetic membranes: A review Shen, Yue-xiao; Saboe, Patrick O.; Sines, Ian T. Journal of Membrane Science, Vol. 454 https://doi.org/10.1016/j.memsci.2013.12.019	journal	March 2014
pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1 Capasso, Melania; DeCoursey, Thomas E.; Dyer, Martin J. S. Trends in Cell Biology, Vol. 21, Issue 1 https://doi.org/10.1016/j.tcb.2010.09.006	journal	January 2011
Atomic Layer Deposition of High-Purity Palladium Films from Pd(hfac) 2 and H 2 and O 2 Plasmas Weber, Matthieu J.; Mackus, Adriaan J. M.; Verheijen, Marcel A. The Journal of Physical Chemistry C, Vol. 118, Issue 16 https://doi.org/10.1021/jp5009412	journal	April 2014
Modeling Ion Transport in Tethered Bilayer Lipid Membranes. 1. Passive Ion Permeation Robertson, Joseph W. F.; Friedrich, Marcel G.; Kibrom, Asmorom The Journal of Physical Chemistry B, Vol. 112, Issue 34 https://doi.org/10.1021/jp800162d	journal	August 2008
In Situ Formation and Characterization of Poly(ethylene glycol)-Supported Lipid Bilayers on Gold Surfaces Munro, Jeffrey C.; Frank, Curtis W. Langmuir, Vol. 20, Issue 24 https://doi.org/10.1021/la048378o	journal	November 2004
Gramicidin forms multi-state rectifying channels Busath, David; Szabo, Gabor Nature, Vol. 294, Issue 5839 https://doi.org/10.1038/294371a0	journal	November 1981
A positive future for squid proteins Rolandi, Marco Nature Chemistry, Vol. 6, Issue 7 https://doi.org/10.1038/nchem.1980	journal	June 2014
Taking electrons out of bioelectronics: bioprotonic memories, transistors, and enzyme logic Hemmatian, Zahra; Miyake, Takeo; Deng, Yingxin Journal of Materials Chemistry C, Vol. 3, Issue 25 https://doi.org/10.1039/C5TC00502G	journal	January 2015
Solution processed liquid metal-conducting polymer hybrid thin films as electrochemical pH-threshold indicators Mitraka, E.; Kergoat, L.; Khan, Z. U. Journal of Materials Chemistry C, Vol. 3, Issue 29 https://doi.org/10.1039/C5TC00753D	journal	January 2015
Self-deployable current sources fabricated from edible materials Kim, Young Jo; Chun, Sang-Eun; Whitacre, Jay Journal of Materials Chemistry B, Vol. 1, Issue 31 https://doi.org/10.1039/c3tb20183j	journal	January 2013
An enzyme logic bioprotonic transducer Miyake, Takeo; Josberger, Erik E.; Keene, Scott APL Materials, Vol. 3, Issue 1 https://doi.org/10.1063/1.4900886	journal	January 2015
Modelling complex solution equilibria. I. Fast, worry-free least-squares refinement of equilibrium constants Potvin, Pierre G. Canadian Journal of Chemistry, Vol. 68, Issue 12 https://doi.org/10.1139/v90-337	journal	December 1990
Alamethicin: A Peptide Model for Voltage Gating and Protein-Membrane Interactions Cafiso, D. S. Annual Review of Biophysics and Biomolecular Structure, Vol. 23, Issue 1 https://doi.org/10.1146/annurev.bb.23.060194.001041	journal	June 1994
Proton semiconductors and energy transduction in biological systems Morowitz, H. J. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 235, Issue 3 https://doi.org/10.1152/ajpregu.1978.235.3.R99	journal	September 1978
Organic Electronics at the Interface with Biology Owens, Róisín M.; Malliaras, George G. MRS Bulletin, Vol. 35, Issue 6 https://doi.org/10.1557/mrs2010.583	journal	June 2010

Cited By (14)

Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine Levin, Michael; Selberg, John; Rolandi, Marco iScience, Vol. 22 https://doi.org/10.1016/j.isci.2019.11.023	journal	December 2019
A protonic biotransducer controlling mitochondrial ATP synthesis Zhang, Z.; Kashiwagi, H.; Kimura, S. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-28435-5	journal	July 2018
A non-enzymatic glucose sensor enabled by bioelectronic pH control Strakosas, Xenofon; Selberg, John; Pansodtee, Pattawong Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-46302-9	journal	July 2019
Electronic control of H+ current in a bioprotonic device with carbon nanotube porins Hemmatian, Zahra; Tunuguntla, Ramya H.; Noy, Aleksandr PLOS ONE, Vol. 14, Issue 2 https://doi.org/10.1371/journal.pone.0212197	journal	February 2019
Energy Conversion at the Cuticle of Living Plants Meder, Fabian; Must, Indrek; Sadeghi, Ali Advanced Functional Materials, Vol. 28, Issue 51 https://doi.org/10.1002/adfm.201806689	journal	October 2018
Soft and Ion‐Conducting Materials in Bioelectronics: From Conducting Polymers to Hydrogels Jia, Manping; Rolandi, Marco Advanced Healthcare Materials, Vol. 9, Issue 5 https://doi.org/10.1002/adhm.201901372	journal	January 2020
A DNA-Threaded ZIF-8 Membrane with High Proton Conductivity and Low Methanol Permeability Guo, Yi; Jiang, Zhongqing; Ying, Wen Advanced Materials, Vol. 30, Issue 2 https://doi.org/10.1002/adma.201705155	journal	November 2017
Taking Electrons out of Bioelectronics: From Bioprotonic Transistors to Ion Channels Strakosas, Xenofon; Selberg, John; Hemmatian, Zahra Advanced Science, Vol. 4, Issue 7 https://doi.org/10.1002/advs.201600527	journal	March 2017
Role of the signal sequence in proteorhodopsin biogenesis in E. coli : Soto-RODRíGUEZ and BANEYX Soto-Rodríguez, Jessica; Baneyx, François Biotechnology and Bioengineering, Vol. 116, Issue 4 https://doi.org/10.1002/bit.26878	journal	December 2018
A Microfluidic Ion Sensor Array Wu, Chunxiao; Selberg, John; Nguyen, Brian Small, Vol. 16, Issue 6 https://doi.org/10.1002/smll.201906436	journal	January 2020
Bio-inspired protonic memristor devices based on metal complexes with proton-coupled electron transfer Hiruma, Yusuke; Yoshikawa, Kai; Haga, Masa-aki Faraday Discussions, Vol. 213 https://doi.org/10.1039/c8fd00098k	journal	January 2019
Enhanced protonic conductivity and IFET behavior in individual proton-doped electrospun chitosan fibers Lee, Woo-Kyung; Pietron, Jeremy J.; Kidwell, David A. Journal of Materials Chemistry C, Vol. 7, Issue 35 https://doi.org/10.1039/c9tc02452b	journal	January 2019
Roadmap on biological pathways for electronic nanofabrication and materials Bathe, Mark; Chrisey, Linda A.; Herr, Daniel J. C. Nano Futures, Vol. 3, Issue 1 https://doi.org/10.1088/2399-1984/aaf7d5	journal	January 2019
Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies Di Mauro, Eduardo; Xu, Ri; Soliveri, Guido MRS Communications, Vol. 7, Issue 2 https://doi.org/10.1557/mrc.2017.33	journal	May 2017

Similar Records

Monitoring and modulating ion traffic in hybrid lipid/polymer vesicles

Journal Article · Mon Jul 31 20:00:00 EDT 2017 · Colloids and Surfaces. B, Biointerfaces · OSTI ID:1399496

An enzyme logic bioprotonic transducer

Journal Article · Wed Dec 31 23:00:00 EST 2014 · APL materials · OSTI ID:22415239

Related Subjects

36 MATERIALS SCIENCE
Science & Technology - Other Topics