Functional metabolomics: from biomarker discovery to metabolome reprogramming

Peng, Bo; Li, Hui; Peng, Xuan-Xian

doi:10.1007/s13238-015-0185-x

Functional metabolomics: from biomarker discovery to metabolome reprogramming

Journal Article · Thu Jul 02 00:00:00 EDT 2015 · Protein & Cell

DOI:https://doi.org/10.1007/s13238-015-0185-x· OSTI ID:1623629

Peng, Bo ^[1]; Li, Hui ^[2]; Peng, Xuan-Xian ^[2]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry; DOE/OSTI
Sun Yat-Sen Univ., Guangzhou (China). School of Life Sciences. MOE Key Lab Aquat Food Safety. School of Life Sciences. State Key Lab. of Biocontrol. Center for Proteomics and Metabolomics

Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying crucial biomarkers responsible for metabolic characteristics and revealing metabolic mechanisms, which construct the content of discovery metabolomics. The crucial biomarkers can be used to reprogram a metabolome, leading to an aimed metabolic strategy to cope with alteration of internal and external environments, naming reprogramming metabolomics here. The striking feature on the similarity of the basic metabolic pathways and components among vastly different species makes the reprogramming metabolomics possible when the engineered metabolites play biological roles in cellular activity as a substrate of enzymes and a regulator to other molecules including proteins. The reprogramming metabolomics approach can be used to clarify metabolic mechanisms of responding to changed internal and external environmental factors and to establish a framework to develop targeted tools for dealing with the changes such as controlling and/or preventing infection with pathogens and enhancing host immunity against pathogens. This review introduces the current state and trends of discovery metabolomics and reprogramming metabolomics and highlights the importance of reprogramming metabolomics.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1623629

Journal Information:: Protein & Cell, Journal Name: Protein & Cell Journal Issue: 9 Vol. 6; ISSN 1674-800X

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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The Relevance of Mass Spectrometry Analysis for Personalized Medicine through Its Successful Application in Cancer “Omics” Ciocan-Cartita, Cristina Alexandra; Jurj, Ancuța; Buse, Mihail International Journal of Molecular Sciences, Vol. 20, Issue 10 https://doi.org/10.3390/ijms20102576	journal	May 2019
Metabolomic Profiling of the Host Response of Tomato (Solanum lycopersicum) Following Infection by Ralstonia solanacearum Zeiss, Dylan R.; Mhlongo, Msizi I.; Tugizimana, Fidele International Journal of Molecular Sciences, Vol. 20, Issue 16 https://doi.org/10.3390/ijms20163945	journal	August 2019
Altered Metabolic Profile and Adipocyte Insulin Resistance Mark Severe Liver Fibrosis in Patients with Chronic Liver Disease Gaggini, Melania; Carli, Fabrizia; Rosso, Chiara International Journal of Molecular Sciences, Vol. 20, Issue 24 https://doi.org/10.3390/ijms20246333	journal	December 2019
Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese Lo, Chi-Jen; Tang, Hsiang-Yu; Huang, Cheng-Yu Journal of Clinical Medicine, Vol. 8, Issue 1 https://doi.org/10.3390/jcm8010013	journal	December 2018
Metabolomic Profiles of Dinophysis acuminata and Dinophysis acuta Using Non-Targeted High-Resolution Mass Spectrometry: Effect of Nutritional Status and Prey García-Portela, María; Reguera, Beatriz; Sibat, Manoella Marine Drugs, Vol. 16, Issue 5 https://doi.org/10.3390/md16050143	journal	April 2018
Stress-Induced Mucus Secretion and Its Composition by a Combination of Proteomics and Metabolomics of the Jellyfish Aurelia coerulea Liu, Wenwen; Mo, Fengfeng; Jiang, Guixian Marine Drugs, Vol. 16, Issue 9 https://doi.org/10.3390/md16090341	journal	September 2018
Dendrobium officinale Polysaccharides Inhibit 1-Methyl-2-Nitro-1-Nitrosoguanidine Induced Precancerous Lesions of Gastric Cancer in Rats through Regulating Wnt/β-Catenin Pathway and Altering Serum Endogenous Metabolites Zhao, Yi; Li, Bingtao; Wang, Gaoyu Molecules, Vol. 24, Issue 14 https://doi.org/10.3390/molecules24142660	journal	July 2019
DI/LC–MS/MS-Based Metabolome Analysis of Plasma Reveals the Effects of Sequestering Agents on the Metabolic Status of Dairy Cows Challenged with Aflatoxin B1 Ogunade, Ibukun; Jiang, Yun; Pech Cervantes, Andres Toxins, Vol. 11, Issue 12 https://doi.org/10.3390/toxins11120693	journal	November 2019
Quantification of serum purine metabolites for distinguishing patients with hepatitis B from hepatocellular carcinoma Zhang, Yu; Yang, Jing; Wang, Jiayi Bioanalysis, Vol. 11, Issue 10 https://doi.org/10.4155/bio-2018-0319	journal	May 2019

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