Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

Neilan, John G.; Schutta, Christopher; Barrera, José; Pisano, Melia; Zsak, Laszlo; Hartwig, Ethan; Rasmussen, Max V.; Kamicker, Barbara J.; Ettyreddy, Damodar; Brough, Douglas E.; Butman, Bryan T.; Brake, David A.

doi:10.1186/s12917-018-1582-1

Title: Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

Journal Article · Wed Aug 29 00:00:00 EDT 2018 · BMC Veterinary Research

DOI:https://doi.org/10.1186/s12917-018-1582-1· OSTI ID:1618781

; Schutta, Christopher; Barrera, José; Pisano, Melia; Zsak, Laszlo; Hartwig, Ethan; Rasmussen, Max V.; Kamicker, Barbara J.; Ettyreddy, Damodar; Brough, Douglas E.; Butman, Bryan T.; Brake, David A.

A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized with a replication-deficient human adenovirus-vectored FMDV A24/Cruzeiro/BRA/55 capsid-based subunit vaccine (AdtA24). In two independent vaccine efficacy trials, AdtA24 was administered once intramuscularly in the neck 7 days prior to contact with FMDV A24/Cruzeiro/BRA/55-infected seeder steers.

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Research Organization:: Oak Ridge Associated Univ., Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: number DE-AC05-06OR23100; AC05-06OR23100

OSTI ID:: 1618781

Alternate ID(s):: OSTI ID: 1626876

Journal Information:: BMC Veterinary Research, Journal Name: BMC Veterinary Research Vol. 14 Journal Issue: 1; ISSN 1746-6148

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 6 works

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